Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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C.1 C.1 Table Annex: 1: Cluster Description coordinator of the study centers C.1.5.1 Cluster coordinator Table 15: Cluster coordinator Coordinator Name Prof. Dr. Tobias Pischon, MPH Institution Town Max Delbrueck Center for Molecular Medicine (MDC) Berlin- Buch 13125 Berlin Institute/department/division Molecular Epidemiology Group Address, telephone, e-mail Robert Roessle Straße 10, 13125 Berlin + 49 30 9406 4563 tobias.pischon@mdc-berlin.de C.1.5.2 Study centers Study center Berlin-North Table 1: Overview of participating institutions and investigators/scientists Table 16: Overview of participating institutions and investigators/scientists Institution Town Principal investigator Institute/department/division e-mail Max Delbrueck Center for Molecular Medicine (MDC) Berlin- Buch 13125 Berlin Prof. Dr. Tobias Pischon, MPH Molecular Epidemiology Group tobias.pischon@mdc-berlin.de Description of the institution responsible for establishing and operating the study center The max delbrueck Center for molecular medicine (mdC) Berlin-Buch combines basic research in molecular biology and genetics with clinical research in the fields of cardiovascular and metabolic diseases, cancer, and function and dysfunction of the nervous system. The MDC and the Charité – University Medical Center Berlin have jointly established the Experimental and Clinical Research Center (ECRC), which is dedicated to translational medical research, in particular human subjects-oriented mechanistic research. Based on this research, MDC scientists and clinicians jointly aim at developing new methods for the diagnosis, prevention, and treatment of cancer, cardiovascular, and neurological diseases. With the appointment of a new professorship and the development of a new research group, MDC has recently expanded its research portfolio to the field of Molecular Epidemiology, with the aim of studying at the molecular level the relationship of genetic, metabolic, and environmental factors with risk and outcome of cardiovascular and metabolic diseases in human populations. Together with the Charité – University Medical Center Berlin, the German Institute of Human Nutrition (DIfE), and the Robert-Koch-Institute, MDC has built up the epidemiologic research network for the metropolitan area Berlin-Brandenburg (EPI2B), which combines 250
251 C.1 Annex: Description of the study centers the existing expertise and thereby provides a platform for epidemiologic research to support the National Cohort. Being part of the Helmholtz association, MDC is among the Helmholtz centers that have taken the initiative for setting up a prospective cohort for chronic disease epidemiology in Germany (Helmholtz cohort). An international epidemiology expert panel evaluated this proposal positively in 2008, which provided specific start-up funds for the planning of the cohort at MDC along with the other Helmholtz institutions involved. As part of the planning phase of the Helmholtz cohort, MDC has set up the working group on cardiovascular diseases which, based on the expertise of its more than 40 members, developed between 2009 and 2010 an expert report with detailed suggestions for scientific approaches and protocols for studying cardiovascular disease in the National Cohort. MDC will coordinate the Cluster Berlin-Brandenburg and establish and operat the study center Berlin-North. In addition, MDC will provide the infrastructure for storage and maintenance of the biological samples within the cluster. Description of the study center Berlin-North The study center will be located in Berlin-Buch in rooms of the Experimental and Clinical Research Center (ECRC). Together with the study centers Berlin-Center and Berlin-South this study center will cover the metropolitan area Berlin-Brandenburg, with a total source population of 4.4 million inhabitants (3.4 million in Berlin and 1.0 million in the adjacent districts of Brandenburg). These three study centers, each recruiting 10,000 study participants, will help to minimize costs and time for the study participants to travel to the centers and increase their willingness to participate. Table 1: Overview of participating institutions and investigators/scientists Study center Berlin-Center Table 17: Overview of participating institutions and investigators/scientists Institution Town Principal investigator Institute/department/division e-mail Co-principal investigator Institute/department/division e-mail Associated scientist Institute/department/division e-mail Charité - University Medical Center Berlin 10117 Berlin Prof. Dr. Stefan N. Willich, MPH, MBA Institute for Social Medicine, Epidemiology, and Health Economics stefan.willich@charite.de Prof. Dr. Peter Heuschmann Center for Stroke Research Berlin (CSB) peter.heuschmann@charite.de PD Dr. Thomas Keil, MSc Institute for Social Medicine, Epidemiology, and Health Economics thomas.keil@charite.de C.1
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The National Cohort A prospective e
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Applicants Applicants Applicants Cl
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Applicants IV
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Executive Summary 2. The National C
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Executive Summary 3. Scientific aim
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Executive Summary essary to address
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Executive Summary 7. Examples for s
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Contents A.2.4 major areas of expos
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Contents A.3.8.2 Social security da
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Contents A.6.4.2 Minimally detectab
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Abbreviations C.2 mEThOdS fOr STATI
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Abbreviations DXA Dual-energy x-ray
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Abbreviations CHS Cardiovascular He
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A.1 A.1 Introduction and overview a
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A.1 A.1 Introduction and overview s
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A.2 A.2. Scientific background and
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design Table 3.2: Des
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A.3 A.3 Study design the participan
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A.3 A.3 Study design with a prepare
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A.3 A.3 Study design rural areas, t
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A.3 A.3 Study design A.3.2 Baseline
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A.3 A.3 Study design Modules 70 Int
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ers to vaccina
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A.3 A.3 Study design certain foods)
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design a resting time
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design genetics of BM
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A.3 A.3 Study design Project title
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A.3 A.3 Study design diseases in va
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A.3 A.3 Study design associations,
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A.3 A.3 Study design Informed Conse
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A.3 A.3 Study design 6. Since being
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A.3 A.3 Study design the possible d
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design Blood In addit
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A.3 A.3 Study design the anterior n
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A.3 A.3 Study design study. For exa
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A.3 A.3 Study design large-size sto
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A.3 A.3 Study design routinely prep
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A.3 A.3 Study design Subjects who m
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A.3 A.3 Study design A.3.6.3 reliab
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A.3 A.3 Study design In addition, a
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A.3 A.3 Study design Disease Questi
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A.3 A.3 Study design Data routinely
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A.3 A.3 Study design tial misclassi
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A.4 A.4 Integrated Data Management
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A.6 A.6 Planned statistical analyse
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A.6 A.6 Table Planned 6.4: Expected
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