Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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C.1 C.1 Annex: Description of the study centers Table 1: Cluster coordinator/co-coordinator C.1.7.1 Cluster coordinator Table 24: Cluster coordinator/co-coordinator Coordinator Name Prof. Dr. Ute Nöthlings Institution Town Christian-Albrechts-University Kiel 24105 Kiel Institute/department/division Section of Epidemiology, Institute for Experimental Medcine Address, telephone, e-mail Arnold-Heller Str. 3, Haus 3 Co-coordinator 24105 Kiel +49 431 597 3677 u.noethlings@iem.uni-kiel.de Name Prof. Dr. Alexander Katalinic Institution Town University of Luebeck 23562 Luebeck Institute/department/division Institute for Clinical Epidemiology and Institute for Cancer Epidemiology Address, telephone, e-mail Ratzeburger Alle 160 C.1.7.2 Study center Study center Kiel 23562 Luebeck +49 451 5005440 alexander.katalinic@uk-sh.de Table 1: Overview of participating institutions and investigators/scientists Table 25: Overview of participating institutions and investigators/scientists Institution Town Principal investigator ( Institute/department/division e-mail Co-principal investigator Institute/department/division e-mail University Hospital Schleswig-Holstein, Campi Kiel and Luebeck 24105 Kiel Prof. Dr. Ute Nöthlings Biobank popgen, Section for Epidemiology Institute for Experimental Medicine Christian-Albrechts-University Kiel u.noethlings@iem.uni-kiel.de Prof. Dr. Alexander Katalinic Institute for Clinical Epidemiology and Institute for Cancer Epidemiology / University of Luebeck alexander.katalinic@uk-sh.de 264
265 C.1 Annex: Description of the study centers Description of the institutions responsible for establishing and operating the study center The Christian-Albrechts-university (CAU) Kiel has long-standing expertise in life sciences research. At medical faculty the Biobank popgen represents an institutionalized infrastructure for recruitment, field work, and biobanking located at the University Hospital Schleswig-Holstein Campus Kiel. Popgen is run by the Section for Epidemiology in the Institute for Experimental medicine. Popgen continuously recruits study participants for ongoing population-based studies. Recruitment generally entails administration of standardized questionnaires, physical examinations, collection and storage of biospecimens (whole blood, serum, RNA, DNA, urine, and stool), accompanied by the ascertainment of specific clinical and phenotypic data. Popgen maintains its large biobank of more than 75,000 study participants in close collaboration with the Institute for Clinical Molecular Biology (ICMB), which also runs the genotyping platform associated with popgen. Popgen has a sophisticated data management system essentially following the data protection concept of TMF, developed in close collaboration with the Institute for Medical Informatics and Statistics (IMIS). The research activities of IMIS are focused upon genetic epidemiology, population genetics and bioinformatics. IMIS hosts one of the German Centers of Expertise in Genetic Epidemiology, established through the German national genome research network (NGFN- 2), and as such co-founded popgen in 2003. Practical experience in the field workfor large prospective cohort studies was also gained by the head of the Section of Epidemiology at previous working places, particularly with the European Prospective Investigation into Cancer and Nutrition-Study (EPIC) – which comprises more than 500,000 study participants across Europe, and the Multiethnic Cohort Study, which consists of more than 215,000 participants of multiethnic origin in Hawaii and Southern California, USA. Both studies use active follow-up procedures, in particular the German part of the EPIC-Study adopted case ascertainment procedures applicable to the German health care infrastructure. The popgen Biobank pursues an active follow-up of selected general populations and disease specific cohorts, which includes repeated participant contact. In 2010, popgen started the first follow-up of the central control population of 1,300 participants. In addition to completing of comprehensive medical and lifestyle (nutrition) questionnaires – also via the web – participants are invited to receive a physical examination at the study center on the campus of the University Hospital in Kiel, which includes blood pressure measurement, ECG, anthropometric measurement, ultrasonography of liver, gallbladder and adipose tissue, and whole-body MRI imaging. Close cooperations with clinical partners in Kiel (cardiology, 1st medical department, radiology) are established. In this study a range of biosamples, including DNA, RNA, blood, serum, plasma, erythrocytes, urine, and stool, are collected. In the popgen 2.0 network (P2N) popgen will interlink with further biobanking activities at the University Hospital Schleswig-Holstein Campus Kiel, including the biobanks of the Comprehensive Cancer Center North, the Institutes of Pathology, Neurosurgery, Pharmacology, the University Lung Center North and the Center for family medicine. This network will assist in tracing study participants and collecting disease-specific biomaterial such as tumor tissue. The university of luebeck (uzl) also has long-standing expertise in epidemiologic research with a history of more than 20 years. To strengthen this expertise in 2009 an academic center of population medicine and health care research (aZBV) was founded as one core area of the university. About 15 institutes/working groups dealing with epidemiology in a wider context are members of the aZBV. It is run by the Department of Population Medicine (SP-PM). The working groups of the Institute for Social Medicine (IfSM) have conducted and coordinated numerous cross-sectional und longitudinal pain- and rheumatic disorder-related surveys in Germany: the European Vertebral Osteoporosis Study EVOS, two population C.1
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The National Cohort A prospective e
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Applicants Applicants Applicants Cl
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Applicants IV
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Executive Summary 2. The National C
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Executive Summary 3. Scientific aim
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Executive Summary essary to address
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Executive Summary 7. Examples for s
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Contents A.2.4 major areas of expos
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Contents A.3.8.2 Social security da
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Contents A.6.4.2 Minimally detectab
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Abbreviations C.2 mEThOdS fOr STATI
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Abbreviations DXA Dual-energy x-ray
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Abbreviations CHS Cardiovascular He
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A.1 A.1 Introduction and overview a
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A.1 A.1 Introduction and overview s
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A.2 A.2. Scientific background and
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design Table 3.2: Des
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A.3 A.3 Study design the participan
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A.3 A.3 Study design with a prepare
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A.3 A.3 Study design rural areas, t
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A.3 A.3 Study design A.3.2 Baseline
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A.3 A.3 Study design Modules 70 Int
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design Table 3.5: Spe
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ers to vaccina
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A.3 A.3 Study design certain foods)
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design a resting time
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design Although the i
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A.3 A.3 Study design hemorrhages (0
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A.3 A.3 Study design genetics of BM
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A.3 A.3 Study design hand grip stre
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A.3 A.3 Study design Project title
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A.3 A.3 Study design diseases in va
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A.3 A.3 Study design associations,
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A.3 A.3 Study design Informed Conse
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A.3 A.3 Study design 6. Since being
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A.3 A.3 Study design the possible d
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design Blood In addit
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A.3 A.3 Study design the anterior n
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A.3 A.3 Study design study. For exa
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A.3 A.3 Study design large-size sto
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A.3 A.3 Study design routinely prep
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A.3 A.3 Study design Subjects who m
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A.3 A.3 Study design A.3.6.3 reliab
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A.3 A.3 Study design In addition, a
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A.3 A.3 Study design Disease Questi
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A.3 A.3 Study design Data routinely
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A.3 A.3 Study design tial misclassi
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A.3 A.3 Study design � The KORA c
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A.4 A.4 Integrated Data Management
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A.5 A.5 Methods for quality assuran
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A.6 A.6 Planned statistical analyse
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A.6 A.6 Table Planned 6.4: Expected
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A.7 A.7 Ethical aspects logical/gen
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