Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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A.3 A.3 Study design Table 3.16: Comparison of the physical examination modules applied in recent European Cohort Studies with the ones planned for the National Cohort study CONSTANCES France The National Cohort UK Biobank LifeGene Sweden 18–69 years N=200,000 0–45 years N=500,000 40–69 years Basic: N=500,000 Enhancement 1: N=200,000 Enhancement 2: N=100,000- 150,000 20–69 years Level 1: N=200,000 Level 2: N=40,000 MRI programme : N=40,000 Full reassessment after 5 years N=200,000 Blood pressure and heart rate X (level 1) X (basic) X X 10-s ECG X (level 1) X 3D Echocardiography # X (level 1) X (level 1) X (pulse wave velocity only, enhancement 1) Combined device (incl. arterial stiffness, ankle brachial index, etc.) # Cardiovascular examinations 140 X (level 2) Carotid ultrasound, intima media thickness# Long-term ECG/apnoe device # X (level 2) OGTT # X (level 2) AGE Reader/ Skin AF # X (level 2) Diabetes-related measurements Cognitive testing X (level 1) X (touch screen, basic) X (senior) Spirometry X (level 1) X (basic) X X NO in exhaled air (FeNO) # X (level 2) Respiratory system X (level 2) Examination of the musculoskeletal system # Musculoskeletal system Tooth count # X (level 1) Oral health Dental examination # X (level 2)
CONSTANCES France The National Cohort UK Biobank LifeGene Sweden Body height and body weight X (level 1) X (basic) X X Waist and hip circumference X (level 1) X (basic) X X BIA X (basic) X Antropometry (incl. bone density) DXA # X (level 1) (heel bone ultrasound, basic) Accelerometer (7 days) X (level 1) X (enhancement 2) Fitness test X (level 2) X (enhancement 2) Physical activity Hand grip strengh X (level 1) X (basic) X (senior) One-leg-stand test X (level 2) X (senior) Ophthalmological measurements X (level 2) X (enhancement 1) X (visual acuity) X (audiometry) X (audiometry) X (enhancement 2) (touch screen questionnaire) Audiometric test X (level 2) (touch screen questionnaire) Sense organ functions 141 Olfactory tests # X (level 2) Whole-body MRI # X (in 40.000) (planned for reassessment) Cardiac MRI # X (in 40.000) (planned for reassessment) MRI Brain MRI # X (in 40.000) (planned for reassessment) # The National Cohort as the only cohort study including these measurements at baseline A.3 Study design Table 3.16: Comparison of the physical examination modules applied in recent European Cohort Studies with the ones planned for the National Cohort study A.3
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The National Cohort A prospective e
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Applicants Applicants Applicants Cl
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Applicants IV
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Executive Summary 2. The National C
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Executive Summary 3. Scientific aim
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Executive Summary essary to address
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Executive Summary 7. Examples for s
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Contents A.2.4 major areas of expos
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Contents A.3.8.2 Social security da
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Contents A.6.4.2 Minimally detectab
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Abbreviations C.2 mEThOdS fOr STATI
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Abbreviations DXA Dual-energy x-ray
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Abbreviations CHS Cardiovascular He
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A.1 A.1 Introduction and overview a
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A.1 A.1 Introduction and overview s
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A.1 A.1 Introduction and overview T
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A.1 A.1 Introduction and overview m
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A.1 A.1 Introduction and overview
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A.1 A.1 Introduction and overview s
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A.1 A.1 Introduction and overview
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A.1 A.1 Introduction and overview t
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A.1 A.1 Introduction and overview A
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A.2 A.2. Scientific background and
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design Table 3.2: Des
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A.3 A.3 Study design Table 3.3: Dis
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A.3 A.3 Study design the participan
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A.3 A.3 Study design with a prepare
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A.3 A.3 Study design rural areas, t
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A.3 A.3 Study design A.3.2 Baseline
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A.3 A.3 Study design Modules 70 Int
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design Table 3.5: Spe
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ers to vaccina
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A.3 A.3 Study design certain foods)
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design a resting time
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A.6 A.6 Planned statistical analyse
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A.7 A.7 Ethical aspects logical/gen
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A.7 A.7 Ethical aspects The more ex
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A.7 A.7 Ethical aspects pants, trav
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A.7 A.7 Ethical aspects Data handli
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A.7 Table 7.2 Availability of ident
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A.7 A.7 Ethical aspects Should bios
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A.7 A.7 Ethical aspects ing finding
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A.7 A.7 Ethical aspects 206
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C.1 C.1 Annex: Description of the s
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C.1 C.1 Table Annex: 1: Cluster Des
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C.2 C.2 Annex: Methods for Statisti
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C.2 Table S6.5: Sample size needed
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C.3 References 17. Keil, U., et al.
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C.3 References 50. Benjamin, E.J.,
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C.3 References 85. Calle, E.E. and
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C.3 References 121. Walter, R., D.J
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C.3 References 155. Ross, R., Ather
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C.3 References 189. Ghiotto, F., et
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C.3 References 225. Schmidt, C.O.,
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C.3 References 260. Eussen, S., et
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C.3 References 294. McCrae, R.R. an
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C.3 References 327. Lynch, J.W., G.
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C.3 References 360. Mair, C., A.V.
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C.3 References 395. Lesourd, B., Nu
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C.3 References 431. Statistisches B
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C.3 References 462. Bundeszentrale
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C.3 References 494. Rammstedt, B. a
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C.3 References 526. Mack, F., et al
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C.3 References 560. Palatini, P., A
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C.3 References 590. Greenland, P.,
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C.3 References 623. Olin, A.C., et
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C.3 References 658. Pate, R.R., J.R
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C.3 References 691. Zenge, M.O., et
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C.3 References 727. Ryu, O.H., et a
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C.3 References 757. BSI-Standard 10
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C.3 References 790. Davis, C.E., et
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C.3 References 822. Hegenscheid, K.
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