Scientific Concept of the National Cohort (status ... - Nationale Kohorte

Table 6.7: Number of cases and controls required for nested case-control studies aiming to test for minimal sensitivity, at prefixed specificity, of a
Table continuous 6.7: diagnostic Number of biomarker cases and or controls test* required for nested case-control studies aiming to test for minimal sensitivity, at prefixed
specificity, of a continuous diagnostic biomarker or test*
var(case biomarker)/var(control biomarker) = 1.0 var(case biomarker)/var(control biomarker) = 2.0
Specificity (1-FPR) Specificity (1-FPR)
0.995 (1-0.005) 0.98 (1-0.02) 0.95 (1-0.05) 0.995 (1-0.005) 0.98 (1-0.02) 0.95 (1-0.05)
control to case ratio control to case ratio control to case ratio control to case ratio control to case ratio control to case ratio
A.6 Planned statistical analyses and statistical power considerations
TPR0 TPR1 2 4 10 2 4 10 2 4 10 2 4 10 2 4 10 2 4 10
0.20 0.25 3435 1950 1058 1508 986 673 1022 743 576 1207 836 613 725 595 516 673 534 492
0.30 1020 575 308 443 287 193 673 337 164 353 241 175 278 169 146 673 337 139
0.35 512 287 153 278 142 95 673 337 135 175 119 85 278 139 71 673 337 135
0.40 312 175 92 278 139 57 673 337 135 106 72 51 278 139 56 673 337 135
189
0.45 209 117 62 278 139 56 673 337 135 71 48 34 278 139 56 673 337 135
0.50 148 83 44 278 139 56 673 337 135 71 36 24 278 139 56 673 337 135
0.55 107 60 32 278 139 56 673 337 135 71 36 18 278 139 56 673 337 135
0.60 78 44 23 278 139 56 673 337 135 71 36 15 278 139 56 673 337 135
0.65 71 36 17 278 139 56 673 337 135 71 36 15 278 139 56 673 337 135
0.70 71 36 15 278 139 56 673 337 135 71 36 15 278 139 56 673 337 135
0.75 71 36 15 278 139 56 673 337 135 71 36 15 278 139 56 673 337 135
A.6