Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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C.1 C.1 Annex: Description of the study centers Description of the institution responsible for establishing and operating of the study center regensburg university was founded in 1962 and was designed as a comprehensive university offering a diverse spectrum of educational and research disciplines. An average of 20,000 students are currently enrolled at Regensburg University. The department of Epidemiology and Preventive medicine at Regensburg University is embedded in the Regensburg University Medical Center, a tertiary care facility that provides inpatient and outpatient diagnostics and therapy for all serious diseases. It accommodates 20 clinical departments and five biomedical institutes and provides the majority of health care in North- Eastern Bavaria, with 29,000 inpatients and 111,000 outpatients being treated here every year. The Faculty of Medicine at Regensburg University Medical Center has made a firm commitment to support a comprehensive research program on disease prevention. As such, there are strong research collaborations between the epidemiology department and clinical partners at the Regensburg University Medical Center, including collaborations in the areas of cardiovascular and metabolic diseases, cancer, neurodegenerative diseases, and biostatistics. Clinical research infrastructure is available at the Regensburg University Medical Center for all pertinent aspects of medical and epidemiologic data collection and analysis, including experienced study personnel (study nurses, data managers, IT specialists, and quality assurance managers), laboratory facilities for blood sampling and biospecimen storage, and in-house facilities for imaging examinations (MRI). The primary areas of research of the Department of Epidemiology and Preventive Medicine at Regensburg University include the interrelationship between body size, energy intake, physical activity, and chronic disease with a focus on cancer. Research encompasses methodological research on the assessment of physical activity and its individual components. Although physical activity measurement techniques have evolved considerably over the past few years, the main obstacle in quantifying physical activity is the complexity of precisely measuring its individual components. In addition, the department is pursuing research to identify of biological mechanisms linking the adverse effects of obesity, energy oversupply, and physical inactivity to disease risk. Possible biological mechanisms include insulin resistance and lipid metabolism, insulin-like growth factors, steroid hormones, immune function, and inflammatory factors. The department also has a strong focus on molecular and genetic epidemiology and it is an active participant of several large consortia, such as GI- ANT (Genetic Investigation of ANThropometric parameters), one of the largest international genetic epidemiology consortia including over 40 studies involving n~120,000 subjects and n~100 researchers. In addition to research, the department provides teaches epidemiology to medical students and students of molecular medicine through lectures, seminars, and mentorships for masters, and doctoral theses. Description of the study center Regensburg The sampling frame for the National Cohort includes a source population of 215,000 inhabitants in Regensburg city and neighboring communities. Under the leadership of M. Leitzmann 10,000 study participants in the age range of 20 - 69 years will be recruited at the study center in Regensburg. The study center includes ample space (approximately 500 m²) for interviews, clinical investigations, blood draws, and interim storage of biosamples. The study center is located within the Regensburg University Medical Center, which is easily accessible to study participants via public transportation or by car. The direct location of the study center at Regensburg University Medical Center and its existing collaborations with numerous clinicians and associated scientists will allow for an optimal conduct and oversight of the study operations and will facilitate identifying and validating a wide range 230
231 C.1 Annex: Description of the study centers of phenotypes relevant to the National Cohort. In addition, the close affiliation with the Regensburg Cancer Registry will be instrumental efficiently and comprehensively tracing study participants, particularly for subjects who develop cancer during follow-up. C.1.2 Cluster Baden-wuerttemberg/Saarland The Cluster Baden-Wuerttemberg/Saarland comprises three study centers in the area of South-West Germany, located in Mannheim, Freiburg, and Saarbruecken. Study Center Ba-Wü/Saarland figure 2: Geographical overview of recruitment areas and study centers for the cluster Baden- Wuerttemberg/Saarland Baden-Wuerttemberg/Saarland SC Heidelberg/ Mannheim DKFZ Heidelberg SC Saarbruecken University Cancer Registry Saarland Heidelberg SC Freiburg Study center (SC) Coordinating institution Participating institution Recruitment areas: Mannheim city Freiburg city County of Emmendingen Saarbruecken city Saar-Palatinate county University Freiburg Heidelberg/ DKFZ Mannheim Saarbrücken Freiburg C.1
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The National Cohort A prospective e
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Applicants Applicants Applicants Cl
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Applicants IV
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Executive Summary 2. The National C
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Executive Summary 3. Scientific aim
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Executive Summary essary to address
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Executive Summary 7. Examples for s
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Contents A.2.4 major areas of expos
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Contents A.3.8.2 Social security da
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Contents A.6.4.2 Minimally detectab
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Abbreviations C.2 mEThOdS fOr STATI
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Abbreviations DXA Dual-energy x-ray
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Abbreviations CHS Cardiovascular He
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A.1 A.1 Introduction and overview a
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A.1 A.1 Introduction and overview s
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A.1 A.1 Introduction and overview T
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A.1 A.1 Introduction and overview A
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A.2 A.2. Scientific background and
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design Table 3.2: Des
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A.3 A.3 Study design Table 3.3: Dis
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A.3 A.3 Study design the participan
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A.3 A.3 Study design with a prepare
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A.3 A.3 Study design rural areas, t
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A.3 A.3 Study design A.3.2 Baseline
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A.3 A.3 Study design Modules 70 Int
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design Table 3.5: Spe
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ers to vaccina
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A.3 A.3 Study design certain foods)
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design a resting time
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design Although the i
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A.3 A.3 Study design air and then t
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A.3 A.3 Study design hemorrhages (0
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A.3 A.3 Study design genetics of BM
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A.3 A.3 Study design hand grip stre
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A.3 A.3 Study design Project title
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A.3 A.3 Study design diseases in va
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A.3 A.3 Study design associations,
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A.3 A.3 Study design Informed Conse
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A.3 A.3 Study design 6. Since being
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A.3 A.3 Study design the possible d
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design Blood In addit
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A.3 A.3 Study design the anterior n
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A.3 A.3 Study design study. For exa
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A.3 A.3 Study design large-size sto
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A.3 A.3 Study design routinely prep
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A.3 A.3 Study design Subjects who m
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A.3 A.3 Study design A.3.6.3 reliab
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A.3 A.3 Study design In addition, a
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A.3 A.3 Study design Disease Questi
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A.3 A.3 Study design Data routinely
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A.3 A.3 Study design tial misclassi
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A.3 A.3 Study design � The KORA c
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A.3 A.3 Study design Table 3.16: Co
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A.4 A.4 Integrated Data Management
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A.5 A.5 Methods for quality assuran
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C.2 C.2 Annex: Methods for Statisti
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C.3 References 17. Keil, U., et al.
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C.3 References 50. Benjamin, E.J.,
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C.3 References 85. Calle, E.E. and
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C.3 References 121. Walter, R., D.J
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C.3 References 155. Ross, R., Ather
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C.3 References 189. Ghiotto, F., et
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C.3 References 225. Schmidt, C.O.,
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C.3 References 260. Eussen, S., et
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C.3 References 294. McCrae, R.R. an
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C.3 References 327. Lynch, J.W., G.
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C.3 References 360. Mair, C., A.V.
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C.3 References 395. Lesourd, B., Nu
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C.3 References 431. Statistisches B
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C.3 References 462. Bundeszentrale
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C.3 References 494. Rammstedt, B. a
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C.3 References 526. Mack, F., et al
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C.3 References 560. Palatini, P., A
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C.3 References 590. Greenland, P.,
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C.3 References 623. Olin, A.C., et
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C.3 References 658. Pate, R.R., J.R
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C.3 References 691. Zenge, M.O., et
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C.3 References 727. Ryu, O.H., et a
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C.3 References 757. BSI-Standard 10
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C.3 References 790. Davis, C.E., et
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C.3 References 822. Hegenscheid, K.
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