Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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C.1 C.1 Annex: Description of the study centers As part of the planning phase of the Helmholtz cohort, DIfE has (together with the German Cancer Research Center, DKFZ) set up the working group physical activity and (together with the Helmholtz-Center Munich) the working group on diet. The two working groups could make use of the expertise of their about 30 members and developed an expert report with detailed suggestions for scientific approaches and protocols for Diet and Physical Activity to be addressed in the National Cohort. The DIfE will establish and operate the study center Berlin-South. Description of the study center Berlin-South/Brandenburg The study center will be located in Berlin-South at the Campus Benjamin Franklin. In this campus, DIfE already supports a metabolic unit established due to a joint professorship with the Charité. The study center in Berlin-South as well as the study centers Berlin-North and Berlin-Center cover the EPI2B metropolitan area Berlin-Brandenburg. It offers nearby examination facilities with a minimum of travel time for those participants living in the southern part of the study area. Table 1: Overview of participating institutions and investigators/scientists Study support center Table 19: Overview of participating institutions and investigators/scientists Institution Town Principal investigator Institute/department/division e-mail Associated scientist e-mail Description of the institution Robert Koch Institut (RKI) Berlin 13302 Berlin Dr. Bärbel-Maria Kurth Department of Epidemiology and Health Reporting KurthB@rki.de PD Dr. Martin Schlaud Department of Epidemiology and Health Reporting SchlaudM@rki.de The robert koch Institute (rkI) is the central federal institution responsible for disease control and prevention and is therefore the central federal reference institution for both applied and response-oriented research and for the public health sector. The Department of Epidemiology and Health Reporting of the RKI is responsible for health reporting to the German federal government and thus for initiating and conducting nationwide health surveys, many of which are embedded in the European Health Monitoring Network. RKI has been conducting large population-based studies for more than 25 years, starting with cross-sectional prevalence studies in the 1980s, and later prospective cohort studies in adults (1990s) and children/adolescents (2000s). Since 2008, a national health monitoring system has been established at the RKI. In this system, representative health interview and examination surveys are conducted according to a schedule of fixed intervals. The aim of the health surveys is to collect up-to-date information on the health and health behavior of the German population, to determine trends over time and to identify risk factors. Furthermore, the additionally integrated panel component makes it possible to reveal temporary sequences, developmental trajectories, and potential causal relations. Currently, one cohort study in adults (n = 8,000) and one cohort study in children/adolescents (n = 17,500) are ongoing. The full planning, development, and testing of survey instruments, recruitment, address management, field work, 254
255 C.1 Annex: Description of the study centers laboratory testing, quality and data management, feed-back of individual results, statistical analysis, critical evaluation, and publication of results is being done by the RKI. Together with MDC, DIfE, and Charité, RKI has jointly established the epidemiologic research network for the metropolitan area Berlin-Brandenburg (EPI2B) to support the National Cohort. Within the context of the National Cohort and based on its extensive experience, the RKI will support the recruitment of study participants. C.1.6 Cluster lower Saxony/hamburg/Bremen The Cluster Lower Saxony/Hamburg/Bremen comprises three study centers in the area of Lower Saxony (Brunswick/Hanover) and the city states of Bremen and Hamburg. Recruitment Cluster Niedersachsen/Hamburg/Bremen figure 6: Geographical overview of recruitment areas and study centers for the cluster Lower Saxony/Hamburg/Bremen Lower Saxony/Hamburg/Bremen UKE SC Bremen SC Hamburg BIPS TiHo Hanover SC Brunswick/Hanover HZI Brunswick Study center (SC) Coordinating institution Participating institution Recruitment areas: Hamburg city Bremen city Delmenhorst city Lilienthal Northern county of Vechta Parts of county of Oldenburg (Municipalities Ganderkesse, Dötlingen, Wildeshausen) Bremen Hamburg BIPS Northeast county of Cloppenburg Municipality Diepholz Municipality Hude Brunswick city County of Peine Eastern region of Hanover Hanover city C.1
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The National Cohort A prospective e
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Applicants Applicants Applicants Cl
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Applicants IV
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Executive Summary 2. The National C
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Executive Summary 3. Scientific aim
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Executive Summary essary to address
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Executive Summary 7. Examples for s
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Contents A.2.4 major areas of expos
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Contents A.3.8.2 Social security da
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Contents A.6.4.2 Minimally detectab
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Abbreviations C.2 mEThOdS fOr STATI
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Abbreviations DXA Dual-energy x-ray
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Abbreviations CHS Cardiovascular He
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A.1 A.1 Introduction and overview a
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A.2 A.2. Scientific background and
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design the participan
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A.3 A.3 Study design A.3.2 Baseline
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A.3 A.3 Study design Modules 70 Int
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ers to vaccina
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A.3 A.3 Study design certain foods)
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design a resting time
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design genetics of BM
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A.3 A.3 Study design Project title
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A.3 A.3 Study design diseases in va
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A.3 A.3 Study design associations,
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A.3 A.3 Study design Informed Conse
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A.3 A.3 Study design 6. Since being
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A.3 A.3 Study design the possible d
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design Blood In addit
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A.3 A.3 Study design the anterior n
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A.3 A.3 Study design study. For exa
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A.3 A.3 Study design A.3.6.3 reliab
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A.3 A.3 Study design In addition, a
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A.3 A.3 Study design Disease Questi
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A.3 A.3 Study design Data routinely
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A.3 A.3 Study design tial misclassi
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A.3 A.3 Study design � The KORA c
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A.4 A.4 Integrated Data Management
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A.5 A.5 Methods for quality assuran
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A.6 A.6 Planned statistical analyse
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A.6 A.6 Table Planned 6.4: Expected
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C.3 References 431. Statistisches B
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C.3 References 462. Bundeszentrale
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