Scientific Concept of the National Cohort (status ... - Nationale Kohorte

115
A.3 Study design
sample drawing, collection, processing, transportation, and storage will be compiled
by the competence unit on biomaterials.
� The concept of collection, preanalytic processing, storage, and retrieval is also shown
in figure 3.3.
figure 3.3: Concept for the collection, processing, storage, and retrieval of biosamples in the
National Cohort
Processing and storage of biosamples
Study Centers Sample storage Scientific use
A
Collection of
biomaterials
SC 1 RegBioRep 1-n
Researcher 1
SC 2
SC 3
SC n
B
Pre-analytic
processing
C
Shipping
Central
Biorepository
Manual working
archive
RegBioRep m
D
Long-term
storage
E
Retrieval
A.3.5.2 Types of biomaterials considered
F
Shipping
Researcher 2
Researcher 3
Researcher n
G
Lab analysis
Blood obviously is considered the most important biomaterial. For biomaterial other than
venous blood, samples will meet several selection criteria:
� The samples will provide major information in addition to that from blood samples in
terms of physiologic coverage or coverage of organ systems (added value).
� No major complications are expected with the collection of the samples (feasibility).
� There is no indication for a major (negative) impact on participation of the invited study
subjects.
� Samples can be processed and stored at appropriate costs.
Different types of biosamples were considered. The reasons for including them are listed in
Table 3.11. Table 3.12 gives an overview of the selected biosamples that shall be collected
from all participants of the National Cohort.
A.3