Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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C.1 C.1 Annex: Description of the study centers Description of the institution responsible for establishing and operating the study center The university of Greifswald, founded in 1456, is one of the oldest universities in Europe. Based on recommendations of the German Science Council, Community Medicine has been developed to a main research field of the Medical Faculty of the University of Greifswald. The Community Medicine Research Network was founded in 1995 and comprises scientists and clinicians of different specialities, including epidemiologists, internists, cardiologists, neurologists, psychiatrists, social scientists, dentists, molecular biologists, pediatricians, and many more. Within this network, not only do the different specialities within the medical faculty collaborate with each other, but also with scientists from different departments. Because after German reunification in 1990, scientifically valid data from East Germany to explain the regional differences in life expectancy were lacking and, consequently, there was a need for population-based research in northeast Germany. The Study of Health in Pomerania (SHIP) thus representing the central tool for the Community Medicine Research Network. The formation of the Institute for Community Medicine in 2002 established permanent institutional structures within the Community Medicine Research Network. Since 2007, SHIP has been integrated in the Institute of Community Medicine as a third section of Clinical-Epidemiologic Research. SHIP is actively involved in multiple national research consortia, such as the Competence Network Heart Failure and the Diabetes Collaborative Research of Epidemiologic Studies (DIAB-CORE), an epidemiologic subproject of the Competence Network Diabetes, and and the Transregio SFB 19 “Inflammatory cardiomyopathy”. SHIP is also part of international research consortia that perform genome-wide association studies. Currently, the overall project consists of two studies, the second examination follow-up of the first SHIP cohort (SHIP-2) and baseline examinations of the second SHIP cohort (SHIP- TREND). Both studies have been designed to investigate the long-term progression of subclinical findings, their determinants and prognostic values (SHIP-2); to analyze the secular trend of subclinical and overt diseases and their determinants in a high-risk population (SHIP-TREND vs SHIP-0); and to assess the prevalence of subclinical findings defined by highly innovative no-invasive methods (SHIP-TREND). The aforementioned details on the comprehensive project of SHIP and the successful efforts with respect to quality assurance reflect the expertise of the existing personnel in implementing recruitment and long-term follow-up of large-scale population-based cohort studies. Given the expertise from SHIP, where data were collected at two examination centers (Stralsund and Greifswald), sufficient experience is available to organize examinations outside Greifswald. There will be regular site visits of the coordinating staff at Neubrandenburg (1 h by car). Description of the study center Neubrandenburg The sample frame is located south of the SHIP region, including the city of Neubrandenburg und the surrounding communities of Uecker-Randow, Demmin, Mueritz, and Mecklenburg- Strelitz. The population living in the study region comprises 281,338 (20–69 years). The central population registry in Mecklenburg-Western Pomerania will be used to draw a population-representative sample of 20,000 participants. The study center Neubrandenburg is located at the Dietrich Bonhoeffer Hospital in Neubrandenburg, an academic teaching hospital of the University Hospital of Greifswald, which provides rooms for investigations, interviews, terminals for self-administered questionnaires and preanalytical preparation and interim storage of biosamples. The location in the hospital supports an optimal conduction of the study, for utilization of the laboratory or the infrastructure for examinations including MRI. The study center is easily accessible by public transport or by car. 270
271 C.1 Annex: Description of the study centers Mecklenburg-Western Pomerania is the least densely populated and one of the economically weakest states in Germany, with an area of more than 23,000 km² and a population of approximately 1.7 million. During the 1980s, mortality of adults living in the East worsened relative to West Germany. In addition to these West-East differences, further regional disparities became evident within East Germany with a South-to-North gradient becoming more and more apparent during the late 1980s. In addition, North-East Germany, which is less industrialized, suffers not only from a decline in birth rates but also from migration of young, healthy and well educated people to metropolitan areas. These determinants add to economic changes. Presently, communities such as Uecker-Randow and Demmin have the highest unemployment and poverty rates in Germany. These changes, although particularly rapid and pronounced, are not limited to this region. Rather, changes observed here are predictive for many other European regions, and therefore North-East Germany may be regarded as a model region for many other parts of Europe. C.1
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The National Cohort A prospective e
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Applicants Applicants Applicants Cl
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Applicants IV
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Executive Summary 2. The National C
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Executive Summary 3. Scientific aim
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Executive Summary essary to address
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Executive Summary 7. Examples for s
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Contents A.2.4 major areas of expos
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Contents A.3.8.2 Social security da
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Contents A.6.4.2 Minimally detectab
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Abbreviations C.2 mEThOdS fOr STATI
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Abbreviations DXA Dual-energy x-ray
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Abbreviations CHS Cardiovascular He
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A.1 A.1 Introduction and overview a
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design depression and
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design study. For exa
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