Journal Thoracic Oncology

Abstracts Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017
years. For Goddard score of emphysematous changes, 28% showed 0 point
and 33% of 1~4 points and more than 21 points occupied only 4%, which
means very low percentages of emphysematous changes for these asbestosrelated
lung cancer, nonetheless of high percentages of heavy smokers. For
pulmonary function test, FEV1.0% is 70.5%±11.3% and %FEV1.0 is 85.6±22.2%.
More than half patients are normal pulmonary function except more than
1,000 of Brinkman index or more than 15 points of Goddard score. From the
classification of GOLD criteria, 54.1% are normal, stage 1 is 20.7%, stage 2
is 22.5 % stage 3 is 1.8% and stage 4 is only 0.9%. Conclusion: Almost all of
asbestos-related lung cancer in Japan are heavy smoker, but 61% showed none
or low grade of emphysematous changes by chest CT and only 2.7% had severe
pulmonary dysfunction.
Keywords: Asbestos, smoking, emphysema lung cancer
POSTER SESSION 1 - P1.01: EPIDEMIOLOGY, TOBACCO CONTROL AND CESSATION/
PREVENTION
TOBACCO, RADON, AIR POLLUTION, OTHER RISK FACTORS –
MONDAY, DECEMBER 5, 2016
Microbiology and Immunology, and Surgery, Dalhousie University, Halifax/NS/
Canada, 3 Beatrice Hunter Cancer Research Institute, Halifax/NS/Canada
Background: Diets rich in polyphenols are well-known to reduce lung cancer
risk among high-risk populations. We analyzed the efficacy of polyphenolsrich
Haskap (Lonicera caerulea L.) fruit extracts in preventing tobacco specific
nitrosamine (TSNA)-induced DNA damage in BEAS-2B lung epithelial cells.
Methods: Monomeric polyphenols of Haskap fruits were extracted in ethanol
and water, and profiled. TSNA, 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) and 4-[(acetoxymethyl) nitrosamino]-1-(3-pyridyl)-1-
butanone (NNKOAc) were used (at sub-lethal concentrations) independently
to induce the carcinogenesis process in BEAS-2B cells. Cell viability assay was
confirmed that the tested concentrations of Haskap extracts were not
cytotoxic to BEAS-2B cells. Results: The Haskap extracts contain diversity of
polyphenols including phenolic acids and flavonoids, however, cyanidin-3-Oglucoside
was the most predominant. Pre-treatment of cells with the Haskap
extracts could significantly reduce the NNK- and NNKOAc-induced DNA
double strand breaks, DNA fragmentation and intracellular reactive oxygen
species, compared to non-treated cells. Immunocytochemistry for H2AXphosphorylation
(Serine 139, red) A. NNKOAc 100 µM, 3 h; B. Haskap ethanol
extract (50 µg/mL, 3 h)+NNKOAc (100 µM, 3 h). DNA counter-staining was
performed with 4,6-diamino-2-phenylindole (blue).
P1.01-014 THE ROLE OF HEREDITARY FACTOR, PROFESSION
AND THE HABIT OF CIGARETTE SMOKING IN DEVELOPING LUNG
CANCER
Irina Pavlovska 1 , Nikola Orovcanec 2 , Biljana Tausanova 2 , Beti Zafirova 2
1 Department of Epidemiology, Institute of Epidemiology and Biostatistics,
Skopje/Macedonia, 2 Department of Epidemiology, Institute of Epidemiology and
Biostatistics, Medical Faculty, Skopje/Macedonia
Background: Lung cancer (LC) is the most common and deadliest cancer
in the world. In the Republic of Macedonia, within the period 2002-2012,
the LC took the first place according to the frequency of appearing in men,
while it was on the fourth place in women. The number of the risk factors is
great being connected with the occurrence of LC. The aim of this study was
to analyze the role of genetic factor, professional exposure and the habit of
cigarette smoking in occurrence of lung cancer. Methods: The research was
conducted as a case-control study. It included 185 patients diseased of LC
(investigated group-IG) and the same number of persons without malignant
disease (control group-CG). In the study were included only interviewees
with pathohistologically confirmed LC. Through calculating the risks of the
Odds ratio (OR), the risk-factors, which had a role in occurrence of the disease,
were quantified, while with the Confidence intervals (CI), the statistical
significance for the error level less 0,05 (p) was defiend. Results: According
to the investigation results, malignant disease of two members in one family
was found in 13,5% of the IG, 9,4% of the CG, respectively. Current smokers
(CS) with present hereditary factor had almost 4 times (OR=3,95; 95%CI, 1,78-
8,77), greater risk to become ill compared to the never smokers (NS) without
hereditary factor. The risk was greater when the same would be compared
to the NS with present hereditary factor (OR=8,76; 95%CI, 1,80-42,68).In
the diseased, the professional exposition was present in 68,6% from IG,
versus 67% in the CG. The highest risk for LC was found in transport workers
(OR=2,50;95%CI, 1,01-6,15) and automehanics (OR=2,31;95%CI, 0,76-7,07).
CS represented 67% of diseased individuals versus 40,5% of the CG. The
risk for them to develop LC was 5,54 (95%CI, 3,0-10,23), times significantly
greater compared to the NS. The risk for the disease was significantly
greater in individuals who were smoking >20years (y), >20cigarettes/day (c/
day), compared to those, who, in the same time period, smoked 20y smoked >20c/day was 2,40 (95%CI, 0,94-6,14), times greater compared
to those, who smoked >20y,