Journal Thoracic Oncology

Abstracts Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017
metastasis (p=0.002). Bone, liver, subcutaneous, and pericardial metastases
showed no such tendencies. Conclusion: There are significant differences in
metastatic organ distributions of central vs. peripheral lung cancers both for
early and late metastases. Central primary tumors are more likely to give rise to
early metastases than peripheral ones. Results of molecular subgroup analyses
will be presented during the Conference.
Keywords: lung adenocarcinoma, primary tumor localization, distant
metastasis, early metastasis
POSTER SESSION 1 - P1.06: ADVANCED NSCLC & CHEMOTHERAPY/TARGETED THERAPY/
IMMUNOTHERAPY
ADVANCED GENERAL –
MONDAY, DECEMBER 5, 2016
Conclusion: NSCLC is associated with significant malnutrition and altered
body composition, especially reduction in the percentage of body fat.
Nutritional interventions must, therefore, be tailored accordingly for these
patients.
Keywords: bioimpedence, lung cancer, body composition
POSTER SESSION 1 - P1.06: ADVANCED NSCLC & CHEMOTHERAPY/TARGETED THERAPY/
IMMUNOTHERAPY
ADVANCED GENERAL –
MONDAY, DECEMBER 5, 2016
P1.06-012 CENTRAL AND PERIPHERAL LUNG ADENOCARCINOMAS
EXHIBIT DIFFERENT TIMING AND PREDILECTION FOR DISTANT
METASTASIS
Thomas Klikovits 1 , Zoltan Lohinai 1 , Katalin Fabian 2 , Márton Gyulai 3 , Andrea
Fodor 4 , Judit Varga 5 , Erika Baranya 6 , Orsolya Pipek 7 , István Csabai 7 , Zoltan
Szallasi 8 , József Tímár 9 , Balazs Hegedus 1 , Balazs Dome 10 , Judit Moldvay 11
1 Division of Thoracic Surgery, Medical University Vienna, Vienna/Austria,
2 Semmelweis University Department of Pulmonology, Budapest/Hungary, 3 Conty
Hospital of Pulmonology, Törökbálint/Hungary, 4 Pulmonology, University of
Debrecen, Debrecen/Hungary, 5 Saint George Hospital of County, Székesfehérvár/
Hungary, 6 National Koranyi Institute of Pulmonology, Budapest/Hungary,
7 Department of Physics of Complex Systems, Eötvös Loránd University, Budapest/
Hungary, 8 Children’S Hospital Informatics Program at the Harvard–Massachusetts
Institute of Technology Division of Health Sciences and Technology, Harvard
Medical School, Boston/AL/United States of America, 9 2nd Department of
Pathology, Budapest/Hungary, 10 Department of Tumor Biology, National Koranyi
Institute of Pulmonology, Budapest/Hungary, 11 Tumor Biology, National Koranyi
Institute of Pulmonology, Budapest/Hungary
Background: Although distant metastases are major factors for unfavorable
prognosis in lung adenocarcinoma (ADC), metastatic patterns have not been
widely analyzed in this malignancy. Methods: Clinicopathological data of
1126 ADC patients (541 men, 585 women, mean age: 62.1 ± 9.4 years, 32-88
years) were studied retrospectively, focusing on the localization of primary
tumor and distant metastases. Metastases diagnosed at the time of primary
tumor diagnosis were defined as early metastases. For statistical analyses,
Fisher’s exact test and a chi-squared independence test were performed.
Results: At time of diagnosis, 621 patients had stage IV disease. 435 of them
had a solitary organ metastasis, mainly in the contralateral lung (n=187), in
the brain (n=66), or in the bone (n=59). During the follow up period another
242 patients developed distant metastasis. 39% of all patients had central
(i.e. endobronchially visible) tumor. In cases with early-, late-, and nonmetastatic
disease, the proportions of central tumors were 43%, 35% and 31%,
respectively. Central primary tumors were significantly more likely to give rise
to early metastases than peripheral ones (p=0.021). When comparing central
and peripheral lung cancers according to their metastatic sites, in central
tumors lung metastases appeared significantly earlier (p=0.017), while in
peripheral ones bone metastases appeared significantly later (p=0.015). There
were significant differences in the metastatic organ distributions of central vs.
peripheral primary tumors for early (p=0.025) and late (p=0.009) metastases.
There was no significant difference in the metastatic organ distributions of
right vs. left lung primaries both for early and late metastases. In right lung
tumors brain metastases appeared later (p=0.047). No significant difference
was observed in the metastatic organ distributions of primary tumors of the
upper vs. lower lobes for early (p=0.051), and late (p=0.528) metastases. Early
appearance was characteristic for lung, pleural, and adrenal involvement
(p