Journal Thoracic Oncology

Abstracts Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017
and virtual media has the potential to bring consistency and uniformity in
diagnosing patients with NSCLC, who are likely to benefit from targeted
therapies. Finally, improvements in efficiency and TAT will inform physicians
on management decisions without any unwarranted delays.
Keywords: liquid biopsy, Molecular testing algorithms, targeted sequencing,
virtual reality
POSTER SESSION 2 – P2.06: SCIENTIFIC CO-OPERATION/RESEARCH GROUPS
LAB, OTHER –
TUESDAY, DECEMBER 6, 2016
P2.06-047 LRRK2-IN-1 INHIBIT PROLIFERATION OF DOUBLECORTIN
AND CAM KINASE-LIKE-1 (DCLK1)-POSITIVE LUNG CANCER CELLS
Hiroyuki Tao, Yuka Mimura-Kimura, Yusuke Mimura, Akio Hara, Daigo
Murakami, Masashi Furukawa, Masataro Hayashi, Kazunori Okabe
Yamaguchi Ube Medical Center, Ube/Japan
Background: Doublecortin and CaM kinase-like-1 (DCLK1) is a kinase that
regulates microtubule polymerization in migrating neurons. DCLK1 is also
suggested to be a tumor stem cell marker in colon and pancreatic cancer.
The expression status of DCLK1 and its role in lung cancer remain largely
unknown. LRRK2-IN-1, a potent therapeutic agent for the treatment of
Parkinson’s disease, has shown to inhibit DCLK1 kinase activity. Methods:
DCLK1 expression status in human non-small cell lung cancer (NSCLC) cell
lines was examined by quantitative real-time RT-PCR and western blotting.
Cell proliferation assay was made after treatments with either si-DCLK1 or
LRRK2-IN-1. Results: DCLK1 was expressed in most of the cell lines examined
in various degrees. In DCLK1-expressing cell lines, si-DCLK1 treatment showed
growth inhibition. LRRK2-IN-1 treatment also showed growth inhibition, in
a dose-dependent manner. Conclusion: DCLK1 can be a target molecule for
NSCLC treatment. LRRK2-IN-1 might be therapeutic for DCLK1-expressing lung
cancer, through inhibition of its kinase activity.
Keywords: Targeted therapy, Doublecortin and CaM kinase-like-1 (DCLK1),
LRRK2-IN-1
POSTER SESSION 2 – P2.07: NURSES
INFORMATION FOR PATIENTS –
TUESDAY, DECEMBER 6, 2016
constructs were companion control, companion agenda and companion
as expert. Companions with a non-negotiated presence were powerful
and expert and moderated information exchange. Conclusion: Companion
accompaniment to lung cancer clinics if often a negotiated process and one
that patients may not have total autonomy over. Accompanying companions
can influence the exchange of clinical information in both a mediating and
moderating manner. The level of negotiated companion presence at lung
cancer consultations has clinical implications that require policy, professional
and patient attention. In order to facilitate the delivery of patient-centred
care and communication healthcare professionals should be aware of and
respect patient preference for companion accompaniment and involvement
when policy initiatives often recommend companion presence during cancer
consultations.
Keywords: mediating and moderating influence, information-exchange, nonnegotiated
accompaniment, clinical consultations
POSTER SESSION 2 – P2.07: NURSES
INFORMATION FOR PATIENTS –
TUESDAY, DECEMBER 6, 2016
P2.07-002 EVALUATION OF PROVIDING HEALTHCARE
INFORMATION FOR LUNG MASS PATIENTS AFTER SURGERY
Daowan Khunyotying 1 , Ladarat Sapinun 1 , Pimpitcha Ratniyom 1 , Somcharoen
Saeteng 2
1 Nursing Service, Chiang Mai University, Chiang Mai/Thailand, 2 Surgery, Chiang Mai
University, Chiang Mai/Thailand
Background: Providing healthcare information is very important for lung mass
patients after lung surgery for achieving good post-operative rehabilitation,
understanding their disease, taking medication, adjusting daily life activity
such as stop smoking, and health promotion. The aim of this study is to
evaluate the providing healthcare information (HI) from physicians or nurses
to patients before discharged and to explore the adding discharge
information needs of patients. Methods: Descriptive research with
prospective data collection design was conducted. All lung mass patients
undergoing lung surgery at General Thoracic Surgery Unit, Department of
Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
during April 1 st , 2015 to July 1 st , 2016 were enrolled in this study. Lung
Information Needs Questionnaire: Thai translation was provided to patients
on the day before discharge date. Results:
P2.07-001 NON-NEGOTIATED COMPANION INFLUENCE
ON INFORMATION EXCHANGE AT LUNG CANCER CLINIC
CONSULTATIONS
Allison Smith 1 , Carol Bugge 2 , Katherine Niven 2
1 Greater Glasgow and Clyde Health Board, Glasgow/United Kingdom, 2 Department
of Nursing and Midwifery, University of Stirling, Stirling/United Kingdom
Background: Effective information exchange is an asset to effective cancer
care (Thorne et al, 2005). Lung cancer is a disease with many biomedical,
physical and psychological consequences. This underlines the need for
patient-centred care, tailoring communication to the specific needs,
values and information preferences of each individual (Kissane et al, 2010).
In the context of patient-centred care, communication with healthcare
professionals can impact the effectiveness of the clinical encounter and
influence clinical outcomes for patients with cancer (Aiello et al, 2008).
However, the way in which healthcare professionals exchange information
with patients can be affected by wide-ranging, external factors. The presence
and involvement of a companion can increase the challenge and complexity
of information exchange during cancer consultations (Albrecht et al, 2010).
Companions add extraordinary dynamics to the clinical interaction and their
potential to influence the exchange, either in a mediating or moderating
manner warrants further investigation. As patients with lung cancer are
commonly accompanied to the consultation by companions and as national
and international policies advocate accompaniment, research in this area
is germane. Methods: Qualitative, multiple case study design. Each case
centred on a patient with lung cancer. It included health professionals
patients consulted with and any accompanying companion(s). Seven cases
were recruited, including 12 companions, and six professionals. Participants
were recruited in 2010-2011 at outpatient clinics. Data were: consultation
recordings, debrief interviews immediately post-consultation and later
in-depth patient (possibly with companion) interviews. Analysis followed
case study pattern matching and coding traditions. Results: Each patient
was accompanied by at least one companion. Three levels of negotiated
companion accompaniment were identified: reciprocal/mutually agreed,
partially negotiated/coerced and non-negotiated. Companions mediated
and moderated information exchange across six major constructs. Mediating
constructs were physical, emotional and informational, and moderating
There were 56 patients enrolled in this study including 18 women and 38 men.
The mean age was 59.16 years (SD= 13.64). The percentage of the physicians or
Copyright © 2016 by the International Association for the Study of Lung Cancer
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