Journal Thoracic Oncology

Abstracts Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017
unclear due to its heterogeneous population. Methods: We retrospectively
reviewed clinicopathological factors of 161 patients who underwent surgical
resection for radiologically diagnosed cN1 NSCLC treated from 2001 to 2013
in our institute. The patients without preoperative invasive mediastinal
evaluation and induction treatment were enrolled. To identify the population
who can benefit from invasive mediastinal staging, we analyzed predictive
factors of pN2 status. Furthermore, disease free survival (DFS), overall
survival (OS) and factors affecting them were also investigated. Results:
One hundred nineteen patients (73.9%) with pN0-1 and 42 patients (26.1%)
of pN2 were identified. More patients of female sex, high serum CEA and
adenocarcinoma (AD) histology were included in the pN2 group (p=0.044,
0.028 and 0.024, respectively). The univariate analyses showed that higher
age and AD histology were potential predictor for pN2 status (p=0.048 and
0.01, respectively) and the multivariate analysis demonstrated AD histology
was a significant predictor for pN2 status (HR: 2.445, p=0.015). Five-year OS
rate of the pN0-1 and pN2 AD patients were 56.8% and 34.0%, respectively
(p=0.46), those of non-AD patients were 70.2% and 64.9%, respectively
(p=0.94). In AD patients, five-year DFS rate of the pN0-1 was 50.2%, which
was significantly better than that of pN2 patients, 5.8% (p