Journal Thoracic Oncology

Abstracts Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017
experimental group (15 cases): the Endostar (15 mg/m 2 , intravenous infusion,
d1-7) synchronization of WBRT (40 Gy/20 fractions/4 weeks); control group (15
cases): WBRT alone. Cerebral blood volume (CBV), blood flow (CBF) and mean
perfusion time (MTT) and lymphocyte analysis were observed by magnetic
resonance perfusion imaging before and 4 weeks after WBRT. Results: In
experimental group, CBF, CBV and MTT at baseline were 582.12±161.42,
524.00±428.64 and 235.00±149.36. Four weeks after treatment, those
perfusion values were 260.00±356.6, 336.00±480.82 and 509.00±44.34
respectively, which showed obvious decreasing trends compared with
baseline data in CBF and CBV, while increased in MTT(Fig 1).
Figure 1 The measurement of MR perfusion imaging of brain.
whole-brain irradiation (WBI) in patients at recently diagnosis with NSCLC
and BM. Methods: From 2009-2015, 231 NSCLC patients with BM were
reviewed for eligibility. Among them, 121 patients with recently diagnosis of
NSCLC, were treated with WBI and have available genotyping status. Results:
EGFR, KRAS, ALK and WT patients were found in 38.0%, 6.6%, 5.8% and
49.6%, respectively. Overall, ORR and disease control rate (DCR) were 62.0%
and 76.8%, respectively. ORR for EGFR, KRAS, ALK and WT patients were
82.6%, 25.0%, 71.4% and 50.0%, respectively (p=0.001). Female gender (OR
2.22 [95% CI: 1.01 – 4.89] P=0.047) and EGFR were associated to better
response to WBI (OR 5.67 [95% CI 2.0-15.8], P = 0.001). A high architectural
histological grade was independently associated with resistance to WBI.
Median IPFS was 9.06 months [95% CI 6.5 -11.4]. IPFS for EGFR, K-RAS,ALK and
WT patients were 11.9, 4.6,12.5 and 6.6 months, respectively (P