Journal Thoracic Oncology

Abstracts Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017
resection of the right pulmonary nodules was performed (Fig.1A-B). The
patient was discharged uneventfully on postoperative day 5. Results:
macroscopically, the nodules had whitish and yellowish colour, smooth
margins, with tense-elastic consistency. Microscopically, an intersecting
bundles of spindle cells with moderate nuclear atypia organized in a fascicular
pattern were clearly evident (Fig.1F). The mitotic activity was more
pronounced than previous histological samples (up to 10 mitoses/10HPF).
Immunohistochemical studies showed positivity for smooth-muscle actin,
desmin, and negativity for HMB-45, CD34, and TTF-1; Ki-67=20% (Fig.1G).
Estrogen and progesterone receptor were weakly positive (Fig.1H). Based on
the current criteria, a diagnosis of low-grade leiomyosarcoma was made. The
patient denied the contralateral surgical resection. Eighteen months later the
chest CT-scan revealed bilateral pulmonary nodules; she is currently under
megesterol acetate treatment.
Squamous cell carcinoma 55.5% (P=0.018).At relation with prevalence at
rural area living place SCC: 51.9% and Urban SCC: 43.7% both (P>0.05).First
motive of consultation was dyspnea Carcinomas of salivary gland type: 66,7%,
carcinomas with pleomorphic sarcomatoid or sarcomatous elements: 50.7%,
Small cell carcinoma: 44,4%, Unclassified: 43.5% Large cell carcinoma: 32.0%,
Adenocarcinoma: 30%, Adenosquamous Carcinoma:30.0%. Coug to Carcinoid
tumors 40%, SCC: 32.4% (P>0.05).Clinical severity correlation to pathologic
classification predominance at stage IV was to carcinomas with pleomorphic
sarcomatoid or sarcomatous elements: 100%, Carcinomas of salivary gland
type: 100%, Adenocarcinoma: 64,9%,Large Cell Carcinoma 60%, Unclassified:
50%. SCC: 43.7%. At stage IIIB Adenosquamous Carcinoma: 100%,
Unclassified: 50%. At IB Carcinoid tumors 50%. Small cell carcinoma advance
stage:69.2%(P=0.000) Conclusion: We found statistical significance relation
between severity grade and histopathology of lung cancer also with gender
prevalence. We hadn’t found statistical significance relation with first motive
of consultation or living place. We had statistical relation at our population
with age groups as bibliographyReferences mentions that is rare to find lung
cancer in young patients, but we found prevalence at 18 to 44 years old of
Squamous cell carcinoma at 39.1% in this age group. Also we found statistical
relation at histopathology type ad clinical severity stage, in our population IV
was predominant. This is the first review of relation between histopathology
with clinical and demographic variables in our Institution.
Keywords: Neoplasm Staging, Lung neoplasms, Pathology
POSTER SESSION 3 – P3.01: BIOLOGY/PATHOLOGY
MORPHOLOGY –
WEDNESDAY, DECEMBER 7, 2016
P3.01-006 PROGNOSTIC IMPACT OF TUMOR SPREAD THROUGH AIR
SPACES IN LIMITED RESECTION FOR PSTAGE I LUNG CANCER
Kyohei Masai 1 , Aoi Sukeda 1 , Akihiko Yoshida 1 , Keisuke Asakura 2 , Kazuo
Nakagawa 2 , Hiroyuki Sakurai 2 , Shun-Ichi Watanabe 2 , Hisao Asamura 3 , Noriko
Motoi 1
1 Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo/
Japan, 2 Thoracic Surgery, National Cancer Center Hospital, Tokyo/Japan, 3 Thoracic
Surgery, Keio University School of Medicine, Tokyo/Japan
Conclusion: BML of the lung is a rare pathological condition with a usually
indolent clinical course. Although it’s exceptional, an evolution towards a low
grade leiomyosarcoma should be considered in the natural history of the
disease.
Keywords: Benign metastasizing leiomyomas lung
POSTER SESSION 3 – P3.01: BIOLOGY/PATHOLOGY
MORPHOLOGY –
WEDNESDAY, DECEMBER 7, 2016
P3.01-005 9 YEAR’S IN ONCOPATHOLOGY AT A LATIN AMERICAN
COUNTRY: DEMOGRAPHIC AND PATHOLOGY CHARACTERIZATION
OF LUNG CANCER AT NATIONAL CANCER INSTITUTE
Silvia Josefina Ayala Leon 1 , Miguel Antonio Aguero Pino 1 , Miguel Ayala Leon 2 ,
Cinthia Viviana Gauna Colás 1 , Alicia Elizabeth Pomata Gunsett 1
1 Asuncion, National Cancer Institute Prof.Manuel Riveros, Asuncion/Paraguay,
2 Mexico, National Institute of Cardiology Ignacio Chavez, Mexico DF/Mexico
Background: This article reviews the pathologic classification of lung
cancer based on the WHO classification of lung tumors and the IASLC/ATS/
ERS classification in our population, we don’t use 2015-WHO classification
because at ongoing of this review wasn’t release yet. Methods: Between
January 2004 and December 2013, all patients diagnosed with a pathology of
SCLC and NSCLC at National Institute of Oncology at Paraguay were analyzed
retrospectively. Demographic information were recorded. SPSS 20 was used
to analyze. Results: We studied 478 subjects. The histological subtypes
found were SCC(Squamous cell carcinoma) : 48.7% and prevalence grade III:
87.3%(P=0.000), Adenocarcinoma: 21%.Prevalence grade II: 50%(P=0.000),
Small cell carcinoma 14%, Large cell carcinoma 75 Prevalence grade III:
100%(P=0.000), Unclassified 6% Prevalence grade III:100%(P=0.000),
Carcinoid tumors 1.3%, Adenosquamous Carcinoma 0.8%, Carcinomas of
salivary gland type 0,8% prevalence grade II: 100%(P=0.000),carcinomas
with pleomorphic sarcomatoid or sarcomatous elements 0.5%. Gender
prevalence at women was SCC: 37.5% and Squamous cell carcinoma at men:
50.3%(P=0.000), Group ages prevalence 18 to 44 years old: Squamous
cell carcinoma 39.1%, 45 to 65: Squamous cell carcinoma 46.3%.>65 years:
Background: Tumor spread through air space (STAS) is proposed as a new factor
of lung cancer invasion, according to the new World Health Organization (WHO)
classification. The aim of this study is to elucidate the prognostic impact and
conduct a histopathological evaluation of STAS in primary lung cancer patients
who underwent limited resection. Methods: We retrospectively collected 508
samples from p-Stage I primary lung cancer patients who underwent limited
resection between 2004 and 2013. Hematoxylin and eosin stained tumor slides
were reviewed to evaluate pathological features, including the presence or
absence of STAS, and the morphological pattern in cases with STAS. We defined
the pattern of STAS as single cell (SG), small cluster (SM), or large cluster (LG).
Clinicopathological characteristics and patient outcome data were collected
from medical records. SPSS statistical software (IBM Corporation, Somers,
NY, USA) was used for statistical analysis. Results: Histological diagnoses
were 440 adenocarcinomas (Ad) (including 107 Adenocarcinoma in situ and 144
Minimally invasive adenocarcinoma), 44 squamous cell carcinomas (Sq), and 24
other types of cancer. Seventy-six cases (15.0%: 60 Ad, 9 Sq, and 7 other types
of cancer) were positive for STAS. The morphological STAS patterns were 12 SG,
45 SM, and 19 LG, respectively. There was no significant relationship between
recurrence rate and morphological STAS pattern. The STAS-positive group was
associated with the presence of micropapillary and/or solid components in Ad,
and with lymphovascular and pleural invasion, compared to the STAS-negative
group (p < 0.01). The median follow-up was 51 months. Eight local recurrences
(1.6%), 16 locoregional (lung parenchyma, hilum, mediastinum) recurrences
(3.1%), and 10 distant recurrences (2.0%) were recorded. In multivariate analysis,
the risk of local (hazard ratio [HR]: 12.75; p < 0.01) and locoregional (HR: 4.12; p
= 0.01) recurrence was significantly higher in the STAS-positive group than in
the STAS-negative group. However, in a multivariate Cox model the presence
of STAS was not associated with distant recurrence (p = 0.58). Conclusion: Our
results indicated that the presence of STAS is a significant risk factor for local
and locoregional recurrence, but not distant recurrence, in p-Stage I lung cancer
following limited resection.
Keywords: lung cancer, STAS, Invasion factor
POSTER SESSION 3 – P3.01: BIOLOGY/PATHOLOGY
MORPHOLOGY –
WEDNESDAY, DECEMBER 7, 2016
P3.01-007 A PULMONARY GLOMUS TIMOR
Satoshi Yamamoto 1 , Takahiro Sawada 1 , Seiji Haraoka 2 , Takafumi Maekawa 3
S588 Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017