Journal Thoracic Oncology

Abstracts Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017
POSTER SESSION 1 - P1.05: EARLY STAGE NSCLC
TRANSLATIONAL RESEARCH & BIOMARKERS –
MONDAY, DECEMBER 5, 2016
P1.05-009 CLINICAL VALUE OF CIRCULATING TUMOR CELL IN THE
DIFFERENTIAL DIAGNOSIS OF SOLITARY PULMONARY NODULE
Lin Wang, Lihua Qiao, Wenjun Yu, Jiatao Lou
Shanghai Chest Hospital, Shanghai/China
Background: The diagnosis of lung cancer suffers from the lack of accurate,
noninvasive and early diagnostic tests. Low-dose helical computed
tomography (LDCT) identifies millions of solitary pulmonary nodules (SPN)
annually, many of which are undiagnosed as either malignant or benign.
When removed surgically, 18%-25% of the nodules are benign, which leads to
unnecessary treatment procedures for surgeons, stress and panic for patients
and waste of medical resources for government. Therefore, an accurate
noninvasive test that can discriminate benign SPN from malignant is urgently
needed. Circulating tumor cells (CTCs) are cells shed from either primary or
secondary tumors that migrate into the circulatory system and exist at the
early stage of cancer. In recent years, CTC has become the research hotspot
because of its great significance in the early diagnosis of cancer, disease
monitoring, prognosis evaluation and guiding individualized treatment.
In this study, we evaluated the application value of CTC in the differential
diagnosis of SPN. Methods: Peripheral blood samples were collected from
134 patients with solitary pulmonary nodule in Shanghai Chest Hospital from
September 2013 to January 2015, including 80 patients with malignant nodule
and 54 with benign nodule. CTC levels of the above subjects were detected
by LT-PCR (ligand-targeted polymerase chain reaction, LT-PCR) assay, and
serum CEA and CYFRA21-1 were detected by flow fluorescence assay. Results:
The CTC levels of malignant SPN patients were significantly higher than that
of benign SPN patients (P