Journal Thoracic Oncology

Abstracts Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017
any modality is feasible with a good PS. Survival is fairly good with surgery or
SBRT.
weight loss was >5% and refractory cachexia if survival was 5% of usual body weight. Mean
pre-cancer body mass index (BMI) was 26.9 (kg/m2), mean BMI at referral was
23.0 (kg/m2). Median survival of non-cachectic and cachectic cohorts were
different (299 vs 188 days respectively, p=0.0078). 24% (73 patients) had
refractory cachexia. Conclusion: Our study shows cachexia is very common
(76%) in lung cancer and affects survival. A quarter of patients had refractory
cachexia. BMI is an insensitive measure of weight loss. Early symptom control
improves survival in lung cancer and this data suggests patients are routinely
being referred too late to a dietitian. Cachexia in lung cancer is a significant
clinical problem. Could upfront assessment of cachexia improve outcome in
patients with advanced lung cancer? We propose to investigate this further.
Keywords: cachexia, metastatic, dietitian, nutrition
POSTER SESSION 1 - P1.06: ADVANCED NSCLC & CHEMOTHERAPY/TARGETED THERAPY/
IMMUNOTHERAPY
ADVANCED GENERAL –
MONDAY, DECEMBER 5, 2016
P1.06-011 ALTERED BODY COMPOSITION AND FAT LOSS IN
ADVANCED NON-SMALL CELL LUNG CANCER
Anant Mohan, Rosemary Poulose, Ashraf Ansari, Randeep Guleria, Karan
Madan, Vijay Hadda, G. Khilnani
Dept of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical
Sciences, New Delhi/India
Background: Assessment of body composition, including fat mass and fat%, is
a useful measure of nutritional status in cancer and may help guide nutritional
interventions. However, these abnormalities have not been well documented
in lung cancer. We aimed to study alterations in parameters of body
composition in Non small cell lung cancer (NSCLC). Methods: A retrospective
chart review was conducted of all newly diagnosed patients with NSCLC. Age
and sex matched healthy controls were recruited prospectively. Disease
staging was done according to the American Joint Committee on Cancer (7th
edition). Performance status was asssessed using the Karnofsky performance
Scale(KPS), and the Eastern Cooperative Oncology Group (ECOG). Details of
body composition including basal Metabolic Rate (BMR), total body water
(TBW), fat mass, and Fat-free mass (FFM) were calculated by bioelectric
impedance method using TANITA TBF 300 body composition analyzer. Results:
A total of 256 patients (83.6% males) and 211 controls (81.5% males) were
studied. The mean (SD) age of patients was 54.5(9.0) years, median smoking
index was 598 (range, 0-2500) and mean duration of symptoms was 158.3(91.7)
days. Median KPS was 80 (range, 40-100). Majority had Stage IV disease
(54.7%), followed by Stage III (41.4%) and Stage II (3.9%). All measured
components of body composition were significantly lower in NSCLC compared
to controls (Table).Among patients with normal body weight (BMI 18.5 – 25
kg/m 2 ), the TBW and FFM were significantly lower compared to their healthy
counterparts.
S346 Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017