Journal Thoracic Oncology

Abstracts Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017
1 Thoracic Surgery, University Hospital, Zürich/Switzerland, 2 Nuclear Medicine
and Radiology, University Hospital, Zürich/Switzerland, 3 Radiology, University
Hospital, Zürich/Switzerland, 4 Engineering, Biostatistics, Zurich University of
Applied Sciences, Winterthur/Switzerland
Background: Although surgical resection remains the optimal treatment for
early-stage NSCLC, up to 50% of patients with stage I and II relapse and die
within 5 years after curative resection. Therefore prognostic markers are
important as these patients might benefit from adjuvant therapy. The goal of
this study was to evaluate established PET quantification metrics including:
maximal standard uptake volume (SUV max
), metabolic tumor volume (MTV)
and total lesion glycolysis (TLG) as prognostic markers for early recurrence
and overall survival in resected early stage lung cancer. Methods: Between
January 2003 and December 2010 182 surgically resected patients with stage
I-II NSCLC who underwent 18 F FDG PET/CT less than one month prior to
surgery have been evaluated. All patients had at least 5 years of follow-up. Cox
proportional hazard model was used to determine the association between
variables and survival respectively time to recurrence. For the multivariate
analysis the following variables have been included: tumor size on CT, age
tumor stage, histology, SUV max
, TLG (for TLG 42%
(threshold at 42% SUV max
)
and TLG 2.5
(cut-off at SUV 2.5) and MTV 42%
and MTV 2.5
). To identify high-risk
patients we used survival trees. Results: 133 patients were included, 71
with adeno carcinoma, 62 with squamous cell carcinoma. TLG 2.5
and MTV 2.5
values have been a significant prognostic factor for recurrence (P