Journal Thoracic Oncology

Abstracts Journal of Thoracic Oncology • Volume 12 Issue S1 January 2017
P3.05-010 DEVELOPING TOOLS FOR A SUCCESSFUL THORACIC
RAPID TISSUE DONATION PROGRAM
Andrea Shaffer 1 , Janella Hudson 2 , Christie Pratt 1 , Teresita Munoz-Antonia 3 ,
Matthew Schabath 4 , Lauren Wilson 2 , Eric Haura 5 , Gwendolyn Quinn 2
1 Thoracic/sarcoma, H Lee Moffitt Cancer Center and Research Institute, Tampa/
FL/United States of America, 2 Health Outcomes and Behavior, H Lee Moffitt
Cancer Center and Research Institute, Tampa/FL/United States of America, 3 Tumor
Biology, H Lee Moffitt Cancer Center and Research Institute, Tampa/FL/United
States of America, 4 Cancer Epidemiology, H Lee Moffitt Cancer Center and Research
Institute, Tampa/FL/United States of America, 5 Thoracic Oncology, H Lee Moffitt
Cancer Center and Research Institute, Tampa/FL/United States of America
Background: Advances in cancer treatment have been made through the use
of human tumor tissues from patients with refractory disease. Rapid Tissue
Donation (RTD) provides an opportunity to gain insight into treatmentresistant
cancers by analyzing tissue from primary tumors and metastasis
within 24 hours following a patient’s death. The discussion of participation
is a delicate process that must consider inherent communication challenges.
Prospective patients may perceive their physician’s recruitment efforts for
RTD as a sign of loss of hope. Companions may be distressed by the offer. This
study examined the decision making of participating in a RTD program for
patients with advanced stage lung cancer and their companion. Methods:
After a physician-guided introduction of the RTD program, participants
with stage 4 lung cancer (n=9) and their companions (n=8) were consented
to participate in a qualitative, semi-structured interview assessing their
decision making process and barriers and benefits of enrolling in the program,
perceptions of the RTD brochures and satisfaction with the recruitment
process. Companions participated in independent and joint interviews
assessing their perceptions of patients’ decision to enroll in the program.
Coders reviewed the verbatim transcripts of the interviews and applied
qualitative thematic analysis to identify emerging themes. Results: The
majority of patients chose to enroll in the RTD program as an opportunity
to give back to science and upon learning organ donation was not an option
for them. All patients had good relationships with their physician and this
was a deciding factor for participation. Patients had limited concerns about
participation and wanted to be sure their loved ones were not burdened by
the process. Companions had more concerns about logistics but all supported
patients’ decisions. All participants were comfortable with the recruiting
process and their physician’s initiation and subsequent discussion of the
program. Several patients indicated that they did not plan to inform extended
family members. Two companions reported feeling distressed during a
clinical discussion concerning the patients’ participation. Patients and
their companions approved of the brochure’s content, includingReferences
to death, but often objected to the use of language depicting cancer as a
“battle” or “fight”. Conclusion: Implementation of an RTD program requires
monitoring of the complex communication processes that occur at both
interpersonal and institutional levels. Additional research during the ongoing
accrual process will continue to assess physician perspectives and seek
methods honoring the wishes of patients and companions. R21 CA 194932-01
(NCI)
Keywords: Rapid Tissue Donation, Ethics, lung cancer
frequent in stages III and IV of lung cancer (24.0% and 22.5% respectively)
than in stages I and II (13.3% and 5.6% respectively). We observed statistically
significant correlation between ECOG PS and risk of malnutrition (p=0.001;
ρ=0.240). Patients with ECOG PS 0 are ten times less likely to have high risk
of malnutrition than patients with poorer ECOG PS. Conclusion: This study
showed that a significant percentage of lung cancer patient have a high risk of
malnutrition therefore it would be advisable to routinely evaluate nutritional
status of lung cancer patients regardless of stages and duration of disease.
Keywords: malnutrition, palliative medicine, lung cancer
POSTER SESSION 3 – P3.05: PALLIATIVE CARE/ETHICS
QUALITY OF LIFE, OTHERS –
WEDNESDAY, DECEMBER 7, 2016
P3.05-012 ASSESSMENT OF THE IMPACT OF PALLIATIVE CARE
ON THE QUALITY OF LIFE IN ADVANCED NON-SMALL CELL LUNG
CANCER PATIENTS - A LONGITUDINAL STUDY
Fawaz Pullishery
Public Health, Educare Institute of Dental Sciences, Malappuram/India
Background: During the last two decades, health-related quality of life
(QoL) measurements have been an important issue in understanding
the difficulties perceived in many diseases. It is important to assess the
health-related quality of life to know the extent of diseases and conditions
affecting individuals general well-being. Studies have shown the effect
various determinants of Quality of Life (QoL) in lung cancer patients. This
study was done to assess the QoL in individuals with non- small cell lung
cancer undergoing palliative care. Methods: Data on QoL were collected using
a modified MOS-SF form-32. The study was done in 27 individuals before and
after providing supportive or palliative care. A random mixed linear model was
used to assess impact of palliative care on Quality of Life with Physical Health
Summary score and Mental Health Summary score as main outcomes. All the
possible confounding factors were controlled in the study. Results: When
values were compared before and after giving palliative care the Physical
Health Summary score decreased considerably. (diff=-2.12; 95% CI: [-4.08,
-0.63]) with small to medium effect sizes. The PHS Score remained lower after
being on palliative care for more than 2 years (diff=-5.86; 95% CI: [-7.89, -3.63]).
]). The Mental Health summary score didn’t change significantly after giving
palliative care (diff=-5.86; 95% CI: [-7.89, -3.63]). The Mental Health summary
score was higher after HAART for more than 5 years when compared prior to
infection. Conclusion: Quality of life is an important determinant in the course
of lung cancer. Palliative or supportive care can play a vital role in improving
the quality of life in patients with lung cancer
Keywords: supportive care, Lung Health, quality of life, Cancer
POSTER SESSION 3 – P3.05: PALLIATIVE CARE/ETHICS
QUALITY OF LIFE, OTHERS –
WEDNESDAY, DECEMBER 7, 2016
POSTER SESSION 3 – P3.05: PALLIATIVE CARE/ETHICS
QUALITY OF LIFE, OTHERS –
WEDNESDAY, DECEMBER 7, 2016
P3.05-011 IMPORTANCE OF ASSESSMENT OF MALNUTRITION RISK
IN LUNG CANCER PATIENTS
Tomi Kovacevic, Bojan Zaric, Darijo Bokan, Jelena Stanic
Clinic for Thoracic Oncology, Institute for Pulmonary Diseases of Vojvodina, Faculty
of Medicine, University of Novi Sad, Sremska Kamenica/Serbia
Background: Malnutrition and cachexia are commonly seen in cancer
patients. The aim of this research was to assess overall risk of malnutrition
in lung cancer patients. Methods: This prospective observational study that
included hospitalized lung cancer patients was conducted in the Institute
for pulmonary diseases of Vojvodina, Serbia. International questionnaire
for nutrition screening was used for clinical assessment of malnutrition.
Subjects were included in this study regardless of lung cancer type, stage of
disease and therapy regiment. Results: Out of total 188 patients included,
76.1% were male and 23.9% female. Majority of patients were in ECOG
performance status (PS) 1 (74.5%) with diagnosed lung cancer in stages III
and IV (39.9% and 42.6% respectively). Most common lung cancer type was
adenocarcinoma (50.0%) followed by sqamous (35.6%), small-cell (10.6) and
other hystologic types (3.7%). Majority of patients had Body Mass Index
(BMI) >20 (87.8%). BMI