European Journal of Scientific Research - EuroJournals

Toxicokinetic Studies of Cadmium and Zinc in Goats Following Intratracheal and
Intravenous Administration of Particulate Matter 353
Figure 5: Linear plot of Zn in Tissues of goat at various times following a single dose of dust (50mg/kg)
intratrachially
Figure 6: Linear plot of Zn in Tissues of goat at various times following a single dose of dust (50mg/kg)
intravenously
Table 1 and 2 show the half –lives and elimination rate constants of chromium and zinc
respectively in serum and various organs following intratracheal and intravenous administration of
dusts to goats. The elimination half life of serum chromium was low lowest (3.0 and 3.3 days) for both
intratracheally and intravenously treated animals, with elimination rate constants of 0.21 and 0.19 per
day. The longest elimination half-life was in the lungs of intratracheally treated animals. The same
observation was made for the zinc with half-lives of 3.3 and 3.6 days respectively for intratracheally
and intravenously treated animals. The elimination half-life was highest (173.2 and 115 days) in the
lungs of intratrachealy treated animals for both cadmium and zinc respectively.