3+4+Supplementum/2012 - Společnost pro pojivové tkáně

marily (secondarily) cause volume
changes η jchp of the examined reactant
components;
c) the effect of chemical substances
(developed in cooperation with
a genome mechanism) which cause
volume changes η jchg of the examined
reactant components; a j is a coefficient
dependent on the value of the equilibrium
state of the tissue.
Results
Principles of thickening in the
bone tissue
1) The speed/speed rate of thickening
in the tissue in the j th biochemical
reaction (for j = 1, 3, 4, 5) initiated by
volume change η jch p e increases, the thickening process
in the bone will be accelerated,
both in the initiation of the thickening
by volume changes η jch influenced by
primary chemical effects, and in the
initiation of the thickening by volume
changes η jm influenced by primary
mechanical effects.
352 14 th Prague-Sydney-Lublin
1 st theorem about the retardation
of bone thickening
Provided that the changes of
mechanical stress in the tissue are
negative (∆p < 0, i.e. p < p e ), thickening
in the tissue is retarded.
2 nd theorem about the acceleration
of bone thickening
Provided that the changes of
mechanical stress in the tissue are
positive (∆p > 0, i.e. p > p e ), thickening
in the tissue is accelerated.
1. The tissue between the bone fragments
had higher density in the medial wall
(in the left femur) while in the lateral
wall the bone density was clearly low
one.
2. Normal negative stresses were redistributed
into the splint. Stress changes in
the medial wall were higher then in
the lateral wall.
3. Redistributions of the stresses (during
the healing), the rate of healing and the
bone quality are influenced directly by
bending rigidity of splints. The biomechanical
effects in the system „splintdiaphysis“
regulate both the quality and
the rate of ossification.
Conclusions
One stage lengthening of the femur
on 2.0–2.5 cm is method of choice for
equalization of the leg length in patients
with achondroplasia and other short stature
patients with congenital or acquired
uneven length of the legs. In these cases
surgical shortening of legs is undesirable.