HYDROPXRICAru)II'M SYI{DROME (ANGARA DISEASE) IN ...

EXPERIMENT'.III
Clinicd Lrl{B ottn. d|sD.
ROUTAS OF HPS INFECTION
Th. deldih ofbnd! inf.cd bv latiou! routc! lrc pr4nl.d in T!bl. lll'l Nonaol$e
e.tact or co rol bird! d.wlop.d cliniel sign! or di.d Son. olth. ftds dicd suddenlv
wirh@r indisti.S ry 3igDt of illn4. Th. dp.im.nt.llv i.f.cLd bndt indicd'n si86 or
drowsinB, tumed folhcB, r.duclion in Lcn i .lc, .nd r.lucl.n@ to mw A 14 orlh'
inLct.d bn& hd vhil. Psty f'e4 b.foc thci. d{lh Pon i.aetion non.hv n'n'd virhi
2-3 d.y!, p.tking on 4 |o 6 d.r! tnd $an dcli.ing on l0 to 12 d.vs Pl All t' $rvivot!
fton UN- tM. l/P .nd hdf ol tho* from th. o6llv i@htcd 8rouP! dd 7 of lh' onlrcl
bn& !ho*.d risl of HPS. Th. body eiShr of i.ft.r.d bndt .t 4 sFl3 ot .g. gft
ilcp€s.d up to 40 p.r al in @mpri$r with lh. @ tol bi.d! Bn& irccul.tcd vir VP
our. di.d a is lh!.lhos in@ht.d ht orh.r roul6 (r.bk lll-|)
Pon Eo.i.m ..d hbtop.rnobSic.l fi.di!8t
aird'' which di.d !ftci HPSV in@hdon o. we lill.d d!.i.4 thc mnbu'd sbg.
hld @Birtc ..d chstuldiltic lsioB on nsoDsy. Thac w! t@md on of cl6r, .mb.r
d g,r{ 6ldr.d gchtimur nuid ii Oc pqddhl {c. Uvd 6 *do, ti.bl. .nd v.llow_
b@wn in @l@r lh@trhrsic &d nuhiptc {4ul.livc nerctic f@i of urying si6,
!@o1.. rnd flny d.s.ndlid. sd psin@l.r innltnlion of mmDder€llt w.
obscd h E litss ol !fl4t.d bn& Mos ol $. d.gd4ltins hepdtoct{e indi4t.d h'e!
rou.d b.$philic inltunuclor incluioi bodid (lNlB) Olhc. frndi.8s i@lud.d d.g4.6liv€
chmsB rd slling of lh. kidn.yr, in $o. d!.., MGt of t$rhr .pnh.lium, lnd
o@iodl hemnnrg6 in Oc i.tc6thi.l ri!su.!. Cedhc ftsB show.d l.ionr tch a
nloordid d.8.rcErio4 o.dm! .nd nomNla c.ll i ltntion, @ns6tior or hlood
!el!, nd edd! i.d Mllin8 of veh. 4doihdium trn8s s.rc o.dmt@s
mngd.n .id htd nononucl.lr 4ll inliltddon. Mic.osPic chligd in rh. bu.e of F.bncius
w. nol @.listori $mc ol th. b!roc w@ hypcnrophi.d whil. olh43 wcrc .tophi.d