HYDROPXRICAru)II'M SYI{DROME (ANGARA DISEASE) IN ...

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Rowe ./ al (19J3) i*r i$hr.d . ctroparhogsic .gcnr froD hutu ad.noids lnd
proposedlheremAdenoidDegodlrionAgenr.Bi[em..andWcrtur(1954)isotaredvitosos
from paliems wirh acut. respnatory i n4 lnd used th. rem R.spi.arory lne$ Ag.nri
llu.hnd cr,t {195.1) @i.ed thr t.m Ad.no Pharynsal Conjuncrivat ag€nr, .nd End.ts
(1e56) p.opoed idcnovirus.s e lh. grorp n.mc lor $oa vitus The rd.marion.l
CoDoiu€e on rhe Trxonony of vitusca .srlbthhed rhe scnN id.novitus into th. tamily
Adenovnidae lhis lamily is now rep!.enicd by iwo sencri senus Maeadcnovitu!
Gdenovirus of nanmdd iid lhc Aviide@ttu! (.denovirus oflvians, F.nm( l97s)
The ch0racteristica of addoviflscs havc b@ detn.d hy wo.kss like ciosbcrg
(1962), Huebner cr a/ (rssa); and willns (1969) The Ad.novinses lrom 0ll speci* dfc
non.nveloped, having icoeholral symm.try .nd oe.runng 700-300 A' in diametcr Th.y
hav. ddsny oa I l4 Cml i. CsCt, and mleul.r @iBht of s p.diclc i about l?t x rd
ddro.s All ad.novitu3 @mrin lindr doublc-slr.nded doxFbonuclac acid (DNA) of 29 x
106 ddhons molecll wcigbt a.d @nsisring of 30 3? Kiloblle pft (Fennercr a/., I99Ji
rnenkelconrat and W.gn r, 1974). Th. icollhedral proiei. shell (capsid) has 0 5:r 2 cubic
symm.lry pan.m (6in$6s ur 41, 1966) ind @cisls of 240 hcxoN (6h bound ro six
ncighbours) Ar th€ .pics, 12 pdtons (ech bond 10 5 rcignbous) whict c.r.y fibrGr !
fihre on e&b penrotr ir M.sndenoviruse, and t{o 6bres on.rch pdton in Aviad.nolioss.
Tho hoxons rre polygotrll prisN wit[ a o.nhl holc (Wilcor s/ a/, 1963) The ponrons,
wh ic h are nore conrp l.x, onsist of similar polygonal bae wirh an it tach.d fibre Tn. fibrcs
v.ry i. ld8th (locrlo A") and .r. 20 A" in diaoet€r. Thc fibre h!re ! teminal knob
nderine a0 A" ir dilm.tcr (Norrby, 1969)
Adaovin6es are rcsistont to ih. .crio. of lipid slvcnti such !s dner (Huebncr rr ,l ,
1954), chlo.oform (Feldm.n and wan8, 196l), fluorocarbons (Wilcox and GinSerg, 1963),
.nd d.oxychohr. (Ho6hll dd T@m, 196r) iidi6ri4 rhit rhcs viNss lek .*ndd lipid3