HYDROPXRICAru)II'M SYI{DROME (ANGARA DISEASE) IN ...

Tryptic dnd chynorrypric pep dc maps, labeted wirh lr:r denoot,alc diffcrdnc.s in
lhc h*ons and imidl proreins CELO vitor od nu@ adaovitus $olyF t Gi e, zl,
1933). Tne ororolyric clakgc parrens indiale rhar whit. $e No h*on, *hibn no
d.t.crable tnilariti.s, rh. rsmiMl proreins h.ve sinildirid i. rhc nuohs .nd sia of rhe
p.ptides genqated by panial proteolysis (Li dral, 1933)
The addovitu! @rc odist3 of . DNA gooru sociared wnh tdr vimt
polyp.ptides. Vnal polyp.prides v, vtt, Xand rlobably vt have been found !o be lsociared
rirh dr€ vnal6r. (8!ciu er at, l9?3, Ru$ellerat, r9?ljNermu! r9s0 md r98?). Bosi{tes
ih. l*o major @rc polr?cpride (v, vll), vi.d Dolypltrnt x d6isnahn I hs ds bcn
tcosn'z.d in th. @r. (tud@n.r al., 1973) Th. im.nd polypeprid.s xl ..d xr dc
id.nriffed by SDS-PAGE but rnese may b. lne cle.vagc iiagmenk ot nigher MW proreins
Pulse chae spoioem Mlh purilicd trepa6lioB of pot?cplids VI, V t, lnd rx
sgad .har VI i.d Vlll D.y reulr fiom clavlgc ol t..8.r p.@.$6 whdd tX b a
lrim.ry uansutio. product (EErirl dnd Philipson, l9?4) Th. @re rroreils ofCELO (FAv)
incbdewIx,XlandXIIwirhMWsoa2o, |2and95KDrqpcdivety(Lierul, l9S4b)
amrdins ro Noi6y ., zl (t9?6) 6vc mjhdu.d prorcins h.v. ban iddin.d
wirh a hng. of MW aron I t - l0O KD Whit. rhc nuibc. 6f non{rrucrudl prot.in! d.nncd by
Wigand dr al (1932) ie nuch gre.ter ond rhcae ate early (15 potrpetrides wilh MW bet*an
| 1.5 and 37 KD), intcmcniat. (potyp4.id. rV0) dd lai. (MW n.ged arofr ll to roo KD)
@cllruLlurai polvp.ptids rynLhdz.d duing rh. r.pt'oron of rhc vituc
Endonuclease activity hd b.eo dctected in asoci.rion wnh $ve.at id.nolitus
s..otyts. ThL scliviry ws alsiltcd wi$ hisl y puriiqt vidonnert.d p.nrons md is
probabry ofho$ ell oigin (Nonty et al , t9r6iw9and et dl., $a2)