HYDROPXRICAru)II'M SYI{DROME (ANGARA DISEASE) IN ...

Th.s vinoN ae rcid sllblc (Hamparian c, a/ , 1963) wjd f.w d@ption j.d , som. sl,ains are
senririle ro pHj (Baber, 1996) ard, in tacr, are more srabte !l acidic rhan th. atkatinc pH
(Wilcox .nd C inshdg, I 961) Th.y arc rho rctaivdy slab!. ir homogedB oa in adred cdh
Adenovitus.s r.p!ic!i. in lhe epirnelium or epitheliumlil. ell culrur.s (Cinsberg,
1958) Adsorption oflhe$ viruss to susc.ptible host celh is relatively slow ln ldenovitus
spei6 ol human o.igin (Ad-2), approxim.|ely ?0.,4 of th. virus re adelbd i. 6 hrs ar
r6"C lt is $emed $,r 12 hrs de ne.d.d for oainun adeQion (Niawstadl ,nd V.n d..
The adenovirus nucleic &id reDli@t6 in $a cell nuclas Pror.ii is s)'th6iz.d in cyloplasm
lnd en is dig.ar.d ro thc nucltus *hqc thc rsnbt trk6 pl.€ (F.nnq e, 4/., 1974) The
asenlbly ofvnal subunits i! vcry iDefici. wirh orly l0-15% ofth€ vnal DNA lnd prclein
becoming t.ds olrb. intrnuol.ir inclusio (Ci.sb.rg ind Dixon, 1959) Borh covddy rr?.
A .nd B int.anucla. imlusione aE quscd by hnous sp4i.s of namMliln and avian
adcnovinscs (MadnM-Palono e/ al, 1957) The cFopihic dl6t oa.doolirus in
susccprible cclk r, v,,/, are characteizd by rounding.nd cl\lmpirg ofthe ccll! (llillcman
and Wernei, l9t4rRos.d/al,1955).nd d.rachm€d ftom thc !u.fe (Norby, I9?lrRov.
er d/ , 1953: voldrin. lnd Pscir4 I %t Tne vitu$s iho povoke an .nhrnc.d utiliation
ofslucor in rhe ell cuhurd le.ding ro an in.rw in orsanic.cid! Tbereiorc, idendtus
n ecred cell cuhu.e have more &idic chdnclcr rhr. ihe noninGcted allur.s (Fisher and
Cirsbe.g, l9t?j Hu.bnd d, at, 1954)
Ad.nottuss 6ni.i. wd .nrig.ns. By using . v.ri.ry of serologictl tehnjqu6t
eroup4pccinc, and subg.oup+pecilio derdminants can be obseNed from $e hexon
DolypeDride aoth sroupip.cilic dd $bSroup-speiic dd.minana m bd ddei.d fion rhe
penron ba$ p'otein, *hilc $b8rdFspafic lnd speiespaif'c d.r.mini.b 4n b. round
on rh. fibrc (Nody, 1969; l9?l) Form.rly, rh. hdons, penlons, od thc fibr.s w.a cilled
antigcns A, B, and C, respeotively (CiNberg, 1962) The hexon a.tis.n is usually