HYDROPXRICAru)II'M SYI{DROME (ANGARA DISEASE) IN ...

Th. oain problcm with any sologidl r.d fo. idoovirus is inreo,.linB fte rNh,,
b@!sc aiibodi€s arc so wid€spred in bolh h.0hny and dbosd bnds, tnd $ mmy bnds
are inf.ct.d wirb a nunb.r of serotypd. Furtn.moq rhc preene of.nribodi.s sv* no
indiolion ol thc stat. of locd illeniry !t thc mucosd !urf.6
Imnutudi|f$ior 0D) T€l
TIic ID rsl i3 widcly used to derecr f/oup sp@ilic otibodios hur i! rctativcly
insensitive.nd m0y only ddd vqy hish inribody ld*.nar s@ndty 3ti6ul{i6n Thi!
iMnivny my nor b. impond in ficld snuaioE *hcc i.pered inferion vith dider.nr
adooliDs seiorypes rdkc pl*e early in lii., eocb su@$i!. inf€lion tuRhs nimulatin8 lhc
gtoup 3t*ific dibody .6po.se Most wo* has b.o cdtn.d oul usins lh. donbl. innuno.
diflrion (DID) i6t, with D €ea .d.fl.d .tnin of IAV-I s fi. ! i8.. (coo\ 1970:
Woeinlc .nd atun.er, 196l) The DID rd n sinDlg inqpcnsivc .nd all r@gnikd solype,
shar. r common pEcipitdting dnlig.n (McF.rdn et ar, 1975)
Al$oush lhe us. of rhe DID r6t for srycy w* sugg6rs that lh. rst is s{siriv.,
thjs is prob.bly do. to ric inf*lid by rcgllrr i$larion llldpq ona lhow . v.ry Do. DID
r6pon!. .ns inferio. by c mruftl ro!t. lf, hovd.r, dE bnd h infected wirh a second
serotyp., a pronounc.d lnd lons laing r.sponse is obtdin.d (Adan, 19?6). Anned and El-
Sisi (196t) f@nd lhal th. g.dtcr n* ir thc nuobd ofbir& wi$ liibody ecuEcd h.t*6n
27 lnd 65 days lncr infccdon Th* r*ults oigh hav. bccn due io r.inf@iion fro6 thcir
penmir.r i rhe 'esulring s.dary r.Qorr. beina detst d Thc lrck of $n!ir iviry of rh. tesl
*is 3hos by cook (19?r, nn.n stc fou.d rh.r only (worhnds oalhc bnd! inf.ded onlly
dw.lopcd d€recbbl. p@ipitim, dd lli! h.d 6l!en to on.rhnd by l0 w@ki How*q,
Cowen ( 1 98?) has shown lh.t if a iriya lcnt lnl iB€n incorpo4tinS l hree ad cnovid s s.rot pes is
used, rh. DID le$ n nuch hore seNiriv.
tdir.ct F1tr6B.dr Andbodt (IFA) fal
Th. IFA r.d ir lhc mosr sonsitivo, rlpid, bd indpcnriv. (Ad.n e, 4/, 1930) in
ge.eral $. foi ddetin8 $. Sroup lnribody. Hosever, il r.qui.d skill ro int.rp.d n Eider