Mar-Abr - Sociedade Brasileira de Oftalmologia

112Campos SBS, Guedes RCA, Costa BLSA, Lima RCR, Oliveira MB, Guimarães NXdevem ter continuidade pelo fato desta substância nãointervir de forma direta no sistema dopaminérgico, acarretandoefeitos adversos.CONCLUSÕESAlterações anatômicas oculares não foram detectadasneste experimento. Novos estudos com dosesdiferentes, em condições de privação visual deverãoser testados.A realização de pesquisas com animais em desenvolvimentofornecem informações para poder utilizartais substâncias no tratamento da ambliopia em crianças,conhecendo-se seus efeitos sobre o crescimentoocular com ou sem privação visual.SUMMARYPurpose: To investigate the occurrence of alterations inthe weight and the diameter of the eyes, and the retinalarea of weaned rats that were submitted to treatment withlevodopa or acetylcysteine, without visual privation.Methods: It was used 31 Wistar rats, that were weaned 21days after they were born. Everyday, between 10 and 14hours,the gavage was made on those animals, with apolystyrene tube introduced into their mouth, until itreached their stomach, so that they received the specificsubstance, forming three groups: levodopa, acetylcysteineand water. After 14 days of treatment, those animals weresacrificed, in order to retreat their eyeball (enucleation),so that they could be weighted and had the anterior-posterior(AP) and equatorial (EQ) diameter measured.Theeyeballs were fixed with 1% paraformaldehyde.Afterwards, the retinas were dissected, opened above agelatinized blade, so that the retinal area could bemeasured. Results: The levodopa and the acetylcysteinegroups showed mean weight, ocular diameter and retinalarea values, similar to those of the control group thatreceived distilled water. Conclusions: Anatomicmodifications were not detected in this experiment. Thestudies with growing animals are important in order toprovide information about certain substances, so that, byknowing their effects on the eyeball growth, with or withoutvisual privation, they can be used in treatment forchildhood amblyopia.Keywords: Levodopa;Acetylcysteine; Eye; Retinal;Biometry;Animal; Rats.REFERÊNCIAS1. Leguire LE, Rogers GL, Walson PD, Bremer DL, McGregorML. Occlusion and levodopa-carbidopa treatment forchildhood amblyopia. J AAPOS. 1998;2:257-64.2. Procianoy E, Fuchs FD, Procianoy F. The effect of incresingdoses of levodopa on children with strabismic amblyopia. JAAPOS. 1999;3:337-40.3. Procianoy E, Fuchs FD, Procianoy F, Procianoy L. Uso delevodopa em pacientes com ambliopia. Arq Bras Oftalmol.2000;63:399-402.4. Gottlob I, Stangler-Zuschrott E. Effect of levodopa on contrastsensitivity and scotomas in human amblyopia. InvestOphthalmol Vis Sci. 1990;31:776-80.5. McBrien NA, Cottriall CL, Annies R. Retinal acetylcholinecontent in normal and myopic eyes: A role in ocular growthcontrol? Vis Neurosci. 2001;18:571-80.6. Papastergiou GI, Schmid GF, Laties AM, PendraK K, Lin T, StoneRA. Induction of axial eye elongation and myopic refractive shiftin one-year-old chickens. Vis Res. 1998;38:1883-8.7. Nastri G, Sellitti L, Benusiglio E. Experimental myopia: therole of the retina (Part I). InterNet J Ophthalmol [serial onthe internet] 1998 [cited 2003 ago 27]; 3. Available from:URL: http://www.unich.it/injo/198.htm8. Iuvone PM, Tigges M, Stone RA, Lambert S, Laties AM. Effectsof apomorphine, a dopamine receptor agonist, on ocularrefraction and axial elongation in a primate model of myopia.Invest Ophthalmol Vis Sci 1991;32:1674-7.9. Mena MA, Davila V, Sulzer D. Neurotrophics effects of L-DOPA in postnatal midbrain dopamine neuron/corticalastrocyte cocultures. J Neurochem 1997;69:1398-408.10. Mena MA, Davila V, Bogaluvsky J, Sulzer D. A synergisticneurotrophic response to L-dihydroxyphenylalanine andnerve growth factor. Mol Pharmacol. 1998;54:678-86.ENDEREÇO PARA CORRESPONDÊNCIAFundação Altino VenturaRua da Soledade, 170 – Boa VistaCEP 50070-040 – Recife (PE) – BrasilTel (0xx81) 3241-4399 / Fax: (0xx81) 3421-8971E-mail: fav@fundacaoaltinoventura.org.brRev Bras Oftalmol. 2005; 64 (2): 109-112