Protocols - Hemorio

Ara-c dose reduction by age:
Age in min Dose %
> 24 100
20-24 90
17-19 80
14-16 70
11-13 60
10-8 50
6-7 40
4-5 30
1000/mm 3 and platelets > 80.000/mm 3
• MO on D1
ARA-C IV 500 mg/m 2 in continuous infusion D 1-4
IDA IV 7 mg/m 2 in 60 minutes D 3, 5
ARA-C IT DOSE BY AGE D1, 6
CONSOLIDATION Part II:
HAM
• Starts 4 weeks after AI
• Good general conditions
• Absence of infection
• PMN > 1000/mm 3 and platelets > 80.000/mm 3
HD ARA-C IV 1g/m 2 in 3 h 12/12 h D 1-3 (total of 6 doses)
MITOX. IV 10 mg/m 2 in 30 minutes. D 3,4
ARA-C IT DOSE BY AGE D1, 6
Note precautions pertaining to the use of ara-c.
4. INTENSIFICATION PHASE:
HAE (to all patients without expected SCT).
• Starts 2-4 weeks after HAM
• Good general conditions
• Absence of infection
• PMN > 1000/mm 3 and platelets> 80.000/mm 3
• MO on D1
HD ARA-C IV 3g/m 2 in 3 h 12/12 h D 1-3 (total of 6 doses)
VP16 IV 125 mg/m 2 in 60 minutes D 2-5
ARA-C IT DOSE BY AGE D1
100