Protocols - Hemorio

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FORMAL CONTRAINDICATIONS TO THE PLATELETS TRANSFUSION: The prophylactic transfusion of platelets is contraindicated in the following clinical situations: Thrombotic Thrombocytopenic Purpura – TTP; Hemolytic-uremic syndrome; HELPP Syndrome; Post-transfusional purpura; Plateletpenia Induced by Heparin TABLE - SUMMARY OF THE INDICATIONS AND CONTRAINDICATIONS OF PLATELET TRANSFUSIONS (RDC 129 as of May 24, 2004) PROPHYLACTIC INDICATIONS THERAPEUTIC INDICATIONS Platelet counting < 20,000 L, in a post-chemo marrow aplasia or radiotherapy. Platelet counting
PLATELET TRANSFUSIONAL YIELD: Key: CPPOS – Post-transfusion platelets counting CPPRE – Pre-transfusion platelets counting PLTR – Total transfused platelets VP – Product volume (ml) (CPPOS – CPRE) X WEIGHT (KG) X 0.075 X 10 6 PLTR X VP X 10 3 HANDLING OF REFRACTORY SUBJECTS: In refractory subjects, the general recommendation is not to transfuse prophylactically, unless you have HLA-compatible platelets. The pre- and post-transfusional platelets counting is recommended in subjects who receive iterative transfusions. The post-transfusional counting can be done after elapsing 10 minutes to 1 hour from the end of transfusion. The optimal situation is to perform the 1- counting between 15 minutes to 1 hour, and after 24 hours after the transfusion is performed. The post-transfusional platelets counting must be mandatory done in the subjects who present, during or right after the transfusion, a febrile reaction with or without chills, chills with no fever or sensation of imminent death. Once the refractivity is confirmed, the subjects must be transfused using the following strategies: SUBJECTS TO WHOM IT IS NOT POSSIBLE TO OBTAIN HLA-COMPATIBLE PLATELETS ABO-compatible platelets. Platelets collected for less than 48 hours. In subjects who are concurrently receiving Amphotericin B, make an interval of 2 hours between the infusion of antibiotic and the transfusion, and vice-versa. If, in spite of those measures, the transfusions are still inefficient, interrupt the prophylactic transfusions and transfuse the subjects only in cases of hemorrhages or before any symptom or sign suggesting intracerebral hemorrhage (therapeutic transfusions). In such cases, the curative transfusions must be done every 8 to 12 hours, until the hemorrhage is controlled. SUBJECTS TO WHOM IT IS POSSIBLE TO OBTAIN HLA-COMPATIBLE PLATELETS: The compatibility may be performed through a cross match or through the selection of donors with HLA phenotype compatible to the subject, or compatible to the antibody(s) that he presents. 165
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PROTOCOLS INSTITUTE OF HAEMATOLOGY
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COORDINATION AND REVISION Clarisse
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SUMMARY: PART I - CLINICAL PROTOCOL
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1.INICIAL CLINICAL EVALUATION SICKL
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TREATMENTO AND IN ADULTS AT ANY AGE
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SPLENECTOMY - INDICATIONS: (1) CHIL
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OUTPATIENT TREATMENT: It is based o
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ASPIRIN AND NSAID PARACETAMOL OPIOI
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CONDUCTION: - Hospitalization - Com
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ONE, TWO-DIMENSIONAL DOPPLER ECHOCA
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Hemianopsia Homonymous deficit of v
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TREATMENT OF CONVULSIVE EPISODES -
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INITIAL ATTENDANCE TO PREGNANT WOME
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- It may occurs acute thoracic synd
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3 Diet with potassium restriction 4
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MICROALBUMINURIA Screening Patients
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RECURRENCE OF PRIAPISM: - Pain Trea
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SPECIAL CARES DEFERASIROX - The use
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TREATAMENT: DRUG Hydroxiurea (hard
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MAJOR AND INTERMIDIATE THALASSEMIA
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HEREDIRATY SPHEROCYTOSIS CLINICAL E
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G6PD DEFICIENCY INITIAL EVALUATION
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LABS EXAMS TO DIAGNOSE APLASTIC ANE
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SELFIMMUNE HEMOLYTIC ANEMIA CONCEPT
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2. Splenectomy: Vaccinate 14 days b
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IMMUNE THROMBOCYTOPENIC PURPURA LAB
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THROMBOTIC THROMBOCYTOPENIC PURPURA
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HEMORRHAGIC SYNDROME INTRODUCTION H
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MULTIDISCIPLINARY FOLLOW-UP OF HEMO
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LYOPHILIZED CONCENTRATES: They are
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TABLE 2: REPLACEMENT THERAPY TO PER
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CONDUCTION IN CONFIRMED INTRACRANIA
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Severe CET with neurological change
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PHARMACOKINETICS OF CLOTTING FACTOR
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INHIBITORS CLASSIFICATION The inhib
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- Extended surgeries require increa
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CLINICAL DIAGNOSIS: According to In
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DDAVP TEST The “test dose” must
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TREATMENT OF BLEEDING SITUATIONS SI
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TABLE 6 - REPLACEMENT THERAPY IN LE
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• Primary prophylaxis: controvers
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CLINICAL AND LABORATORIAL FOLLOW-UP
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MYELODISPLASIC SYNDROME LABORATORIA
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If EPO < 500 mU/ml : EPO (8000U 3x/
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ACUTE MYELOID LEUKEMIA LABORATORIAL
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LMA LMA M3 - non-M3 LMA Protocol LM
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Key: Volunteer to aggressive treatm
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Acute Promyelocytic Leukemia Transf
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BMP LMA IN CHILDREN AND TEENAGERS
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Ara-c dose reduction by age: Age in
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ATRA RECOMMENDATION: ATRA is starte
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- venous hydration - leukapheresis
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POLYCYTHEMIA VERA LABORATORIAL TEST
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TREATMENT - 2nd LINE - Indicated fo
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ACUTE LYMPHOID LEUKEMIA LABORATORIA
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RE-INDUCTION Phase I (weeks 1-4) -
Page 114 and 115: Cycles 2, 4, 6, 8 - Methotrexate 20
Page 116 and 117: PHASE 2 Infusion CPM in 1 hour 1000
Page 118 and 119: CURATIVE RADIOTHERAPY of CNS < 1 ye
Page 120 and 121: CHRONIC LYMPHOCYTIC LEUKEMIA LABORA
Page 122 and 123: fludarabine 25 mg/m VENOUS 2 D1-D3
Page 124 and 125: TRICHOLEUKEMIA LABORATORIAL TESTS -
Page 126 and 127: - age >45 years old - leukocytosis
Page 128 and 129: - Leukemia / T-Cell Lymphoma in Adu
Page 130 and 131: INDICATIONS FOR THE TREATMENT: Symp
Page 132 and 133: 1 st line Chemotherapy R- CHOP (21
Page 134 and 135: CODOX- M/IVAC Cycles 1 and 3 Cyclop
Page 136 and 137: BLOCK A DEXA VO/IV 10 mg /m2 in 3 d
Page 138 and 139: - Surgical treatment is only indica
Page 140 and 141: LEUKEMIA / T-CELLS LYMPHOMA OF THE
Page 142 and 143: HN2 or PUVA (similar to the located
Page 144 and 145: MULTIPLE MYELOMA LABORATORIAL TESTS
Page 146 and 147: RESPONSE CRITERIA Full Response Abs
Page 148 and 149: WALDENSTRON MACROGLOBULINEMIA LABOR
Page 150 and 151: − If HLA-identical related donor
Page 152 and 153: TREATMENT PROTOCOL - ACUTE MYELOID
Page 154 and 155: TREATMENT PROTOCOL - MULTIPLE MYELO
Page 156 and 157: Post-autologous transplantation pro
Page 158 and 159: PART II - TRANSFUSIONAL PROTOCOLS A
Page 160 and 161: PRESERVATION AND CONSERVATION: The
Page 162 and 163: TRANSFUSION OF RED BLOOD CELLS, PLA
Page 166 and 167: 1 - TRANSFUSION OF FROZEN FRESH PLA
Page 168 and 169: COMMUNICATION FORM OF CRYOPRECIPITA
Page 170 and 171: Volume to be = changed (*) VOLEMIA
Page 172 and 173: HEMOTHERAPIC PROTOCOL TO FALCIFORM
Page 174 and 175: 5 - TRANSFUSIONAL CONDUCT AT THE SE
Page 176 and 177: CML - Subjects with symptoms relate
Page 178 and 179: - Aplastic anemia bearers - HIV pos
Page 180 and 181: Severe reaction: anaphylactic shock
Page 182 and 183: - Heart monitoring - Prescribe Furo
Page 184 and 185: CARES AT THE PLATELETS CONCENTRATE
Page 186 and 187: ATTACHMENT I - HEMATOLOGICAL CLINIC
Page 188 and 189: INFECTIOUS SPLENO MEGALIES IMMUNO L
Page 190 and 191: INVESTIGATION OF HEMORRHAGIC SYNDRO
Page 192 and 193: INVESTIGATION OF POLYGLOBULIAS: POL
Page 194 and 195: ATTACHMENT III - HEMATOLOGY SPECIAL
Page 196 and 197: IMMUNOPHENOTYPE PROFILE OF THE ACUT
Page 198 and 199: ATTACHMENT IV - PAIN APPROACH ROUTI
Page 200 and 201: If it is prescribed for more than 1
Page 202 and 203: HOW TO PRESCRIBE OPIOID: SPECIAL CA
Page 204 and 205: SPECIFICITIES OF EACH OPIATE (cont
Page 206 and 207: METHADONE Intravenous (*) Oral path
Page 208 and 209: Psychic Dependence or “addiction
Page 210 and 211: CROSS TOLERANCE - The subject must
Page 212 and 213: ATTACHMENT V - CHEMOTHERAPY SUBJECT
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ATTACHMENT VII - IRON CHELATION GEN
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10. G N N - DFP DFP-100 mg/kg/day d
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ATTACHMENT VIII - SEDATION IN CHILD
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224 NOTES _________________________
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224 NOTES _________________________
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Expresso Gráfica e Editora Ltda-me
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Protocols - Hemorio

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