Protocols - Hemorio

IMMUNOPHENOTYPE PROFILE OF THE ACUTE MYELOID LEUKEMIAS:
LMA HLADr TdT CD34 CD13 CD33 CD15 CD14 CD11b CD61
196
CD41
aMPO
M0 + +/- + + +/ - - /+ - /+ - /+ - +
M1/2 + - /+ + + + + - + - +
M3 - - - /+ +/ - + + - + - +
M4 +/ - - /+ +/ - +/ - + - /+ +/ - +/- - +/ -
M5 + - /+ +/ - +/ - +/ - - +/ - - - +/ -
M6 +/ - - - - +/ - - - - - - /+
M7 +/ - - +/- - +/ - - - - + - /+
IMMUNOPHENOTYPE FOR PLATELET GLYCOPROTEIN: This test is performed in recent collected
plasma. The immunophenotype expression is compared to a control with normal expression.
CD41 CD42b CD61
Bernard Soulier Syndrome Normal expression Decreased
expression
Normal expression
Glanzmann
Decreased
Normal expression Decreased expression
Thrombasthenia
expression
Chromosomal
Abnormality
t(9;22)(q34;q11)
protein p190
t(9;22)(q34;q11)
protein p210
Genes Involved Immunophenotype FAB
BCR-ABL LLA pre B L1/L2
BCR-ABL
t(4;11)(q21;q23) MLL-AF4
LLA pre B
CML
CD10(-) LLA precursor B
or pre-B with my+
L1/L2
L1/L2
t(1;19)(q23;p13) E2A-PBX1 LLA pre B L1/L2
t(12;21)(p12;q22) TEL-AML1 LLA precursor B/ pre B L1/L2
t(15;17)(q22;q21.1) PML-RARα LMA M3 M3 / M3v
t(8;21)(q22;q22) ETO-AML1 LMA M2 / LMA M1 M2/M1
Inv(16)(p13q22 CBFβ-MYH11 LMA M4 M4 / M4eo