Protocols - Hemorio

BLOCKS 1, 3, 5, 7: Hiper-CVAD
CPM IV 300mg/m 2 /d every 12h total 6 doses D 1-3
MESNA IV 600 mg/m 2 /d continuous infusion D 1-3
DEXA IV/VO 40 mg /day D 1-4, D11-14
VCR IV 2 mg /d D 4,11
DOXO IV 50 mg/m 2 /d D 4
G-CSF IV/SC 10 mcg /kg/day ( *) From D 5
(*) Up to leukometry > 3,000/mm 3 and platelets > 60,000/mm 3
BLOCKS 2, 4, 6 AND 8: HD-MTX- Ara-c
MTX
IV 200 mg/m2 IV
in 2 hours D 1
800 mg/m2 continuous infusion in 24h D 1
LCV IV 15 mg every 6 h 8 doses Start 24 h. after the conclusion of MTX
HD-ARA-C IV 3g/m2 in 2 hours every 12 h D 2-3
Methylprednisolone IV 50 mg every 12 hours D 1-3
G-CSF IV/SC 10 mcg /kg/day * From D 5
CNS Prophylaxis
MTX IT 12 mg D 2 of each cycle
ARA-C IT 100 mg D 6 of each cycle
SUPPORT MEASURES: Antimicrobial prophylaxis
Ciprofloxacin 500 mg every 12 h
Fluconazole 200 mg once a day
Acyclovir 200 mg every 12 h
SMZ-TMP 2 tabl twice a day 3 times a week
MAINTENANCE: FOR 2 YEARS - POMP
6-MP VO 50 mg 3x day continuous
MTX VO 20mg/m 2 weekly
VCR IV 2 mg monthly
PRED VO 200 mg For 5 days, together with Vcr.
Note: protocol created for adults. To see the dosages in absolute values, consider SC ∆ 1.7-1.8 m 2 .
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