Protocols - Hemorio

VP 6 hours before do ara-c
Note precautions pertaining to the use of ara-c.
5. MAINTENANCE: 1 year.
Starts 4 weeks after the end of intensification, in parallel with radiotherapy, since general-hematological
conditions allow.
ARA-C SC 40 mg/m 2 D1-4 every 4 weeks
TG VO 40 mg/m 2 daily
ARA-C IT By age D1, 8,15 and, 22
Leukometry mm
TG
3 Dose %
> 3000 150
> 2000 100
>1000-2000 50
< 1000 0
ARA-C: leukometry > 2000/mm3 and platelets> 80.000/mm3; in case the criteria are not fulfilled, postpone
1 week.
CNS TREATMENT:
Age Prophylactic dose Therapeutic dose
15 m -24 m 12 Gy 15 Gy
2-3-years-old 12 Gy 18 Gy
> 3-years-old 12 Gy 18 Gy
LMA IN CHILDREN WITH DOWN SYNDROME:
Patients with Down Syndrome will be treated as Protocol patients, but with the following changes:
1. Ara-c dose reduction as in children younger than 2-years-old.
2. During induction (AIE), Idarubicin dose reduction: 8 mg/m 2 .
3. They will not receive pack .
4. IDA dose reduction on AI pack (5 mg/m 2 ) and MITOX on HAM pack (7 mg/m 2 ).
5. CNS treatment limited to 7 ara-c IT doses.
LMA M3
Patients with M3 are treated in standard risk, regardless the number of blasts on induction’s D15.
Chemotherapy will remain following the patient’s clinical conditions.
Patients with positive molecular marker after HAE pack, will receive ATRA until the marker is negative,
and after HAM pack.
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