Protocols - Hemorio

If it is prescribed for more than 15 days, you must protect the digestive mucosa with antagonist drugs of
the H2 receptors and proton pump blockers, such as Omeprazole, because the act with a different
mechanism and protect more the gastric mucosa.
DOSES:
DIPIRONA PRESENTATION DOSE PERIOD
Tablets 500 mg 1 tablet
Ampule 2 and 5 mg (1ml = 500 1 ampule IM or IV
ADULTS
mg)
Suppository (1g) 1 suppository
Drops (500 mg/ml) 1 drop/Kg (maximum 40
Oral solution (500 mg/ml)
drops)
0.5 g/ml
Up to every 4 h
Tablets 500 mg 1 tablet (children > 30 Kg)
CHILDREN
Injectable solution (0.5g/ml) IM, IV 0.05 ml/Kg/dose (+
2ml/dose)
Suppository (0.3 g) 1 supp (children with 10 – 20
Kg)
AAS PRESENTATION DOSE PERIOD
ADULTS
CHILDREN
Tablets 500 mg
Tablets 100 mg and 500 mg
60 – 90 mg/kg/day
50 – 100 mg/kg/day
Up to every 4 h
Acetaminophen
Paracetamol
PRESENTATION DOSE PERIOD
ADULTS Tablets 500 mg and 750 mg 1 tablet
Drops (200 mg/ml) 1 g/Kg/dose
CHILDREN Oral solution 0.4 mg/Kg/dose
Tablets 500 mg 1 tablet (children > 30 Kg)
ADVERSE EFFECTS:
Dyspepsia, nauseas,
vomits and
epigastralgia
Gastric Ulceration and
Digestive Bleeding
Nephritis and Renal
failure
Anaphylactic
Reactions
Inhibition of the
thrombo-platelet
formation
Hepatic and Bone
marrow Changes
200
Up to every 4 h
It seems to be related to the acidity profile of the drug and to the half-life. Drugs
with a shorter half-life (e.g., aspirin and indomethacin), are more related to those
adverse effects.
They do not present a relation to the acidity degree of the drug, they are late
effects, they result from the inhibition of the prostaglandin synthesis for a long
term, causing a more fluid mucous, with a less quantity of mucin, so less
protective of the mucosa, resulting in an hyperchlorydria by the inhibition of the
release control reflex of acetylcholine at the vagal ends of the stomach. It may
occur with any derivative, especially with drugs having a most extended action.
It may occur at a long-term treatment, mainly in subjects with previous renal
disease. The drug that is the most related to this effect is paracetamol.
Mainly asthma and dermatologic reactions, by the inhibition of the oxygenase
cycle, causing an accumulation of its metabolites, such as leukotriene, resulting
in spasm of the plain muscles of the bronchios. Evaluate a previous history of
rhinitis and asthma. If there is any anaphylactoid reaction, it might occur with
other drugs from the group, except for paracetamol.
Increases the time of bleeding, more frequent in the drugs that inhibit
permanently the cyclooxigenase (aspirin).
Rare.
4 - NON STEROIDAL ANTI-INFLAMMATORY (AINES)