Protocols - Hemorio

INVESTIGATION OF POLYGLOBULIAS:
POLYCYTHEMIA VERA (PV) – DIAGNOSIS CRITERIA (WHO)
A1 - HCT > 60% in men and > 56% in women
A2 - Absence of secondary causes of erythrocytosis (saturation of O2 > 92% + normal EPO)
A3 - Palpable splenomegaly at the physical exam
A4 - Clonality marker (mutation JAK2)
B1 - PLTS > 450,000/mm 3
B2 - LEUK > 10,000 /mm 3 or 12,000/mm 3 in tabagists
B3 - Splenomegaly demonstrated by USG
B4 - Low EPO
POLYCYTHEMIA VERA = A1 + A2 + A3 or A1 + A2 + 2 criteria B
DIAGNOSIS ALGORITHM OF POLYCYTHEMIA VERA
ERYTHROCYTOSIS
(HB ≥ 18.5 (M) > 16.5% (F))
Sat O2 – N / ↓
WITH Splene
WITH Thrombocytosis
WITH Leukocytosis
Serum EPO
NORMAL / LOW HIGH
MO / BO
Sat O2 – N / ↓
WITHOUT Splene
WITHOUT Thrombocytosis
WITHOUT Leukocytosis
PV (+) PV (-)
PV Reevaluate in 3 m
192
Secondary
Polyglobulia
DISCHARGE FROM
HEMORIO