Protocols - Hemorio
Protocols - Hemorio
Protocols - Hemorio
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CHEMOTHERAPY SCHEMES<br />
If hyperleukocitary, perform cytoreduction com Hydrea or Aracythin until leukometry < 30000 to start the<br />
protocol.<br />
Induction - 7 + 3<br />
• Ara-C 100mg/m 2 /d EV IC 24 h D1 – D7<br />
• Idarubicin 12mg/m2/d EV D1 – D3<br />
5 + 2<br />
• Ara-C 100mg/m2/d EV IC 24h D1 - D5<br />
• Daunoblastin 45mg/m2/d EV D1 and D2<br />
Intensification - HDAC<br />
• Ara-C 3g/m 2 12/12h infusion 3h D1 – D3 Total 6 doses.<br />
• G-CSF 5mcg/kg/day, start 24 hours after end and kept until medullar recovery<br />
Attention:<br />
• Eyewash Dexametasone 1gt AO 6/6h<br />
• Monitor cerebellar toxicity: in case of ataxy, nystagmus – ultimate counter-indication<br />
• Dose reduction to 1g/m 2 if > 65 –years-old or Cl Cr < 50<br />
Intervals between cycles<br />
As soon as there is hematological recovery (Neutr>1500, increasing; Plat>100000)<br />
RELAPSE SCHEMES<br />
MEC<br />
• Mitoxantrone 6mg/m 2 EV bolus D1 – D6. Infuse after Ara-C.<br />
• Etoposide 80mg/m 2 /d EV 1h D1 – D6<br />
• Ara-C 1g/m 2 /d EV Infuse in 6h. D1 – D6. Immediately after Etoposide.<br />
• G – CSF 5mg/Kg/day D7 until MO recovery<br />
FLAG – IDA<br />
• Fludarabine 30mg/m 2 D1 – D5. Infuse in 30 minutes.<br />
• Ara-C 2g/m 2 EV D1 – D5 for 2 h. Start 4 h after the beginning of Fludarabine<br />
• Idarubicin 10mg/m 2 D1 – D3<br />
• G – CSF 5mg/Kg/day D6 until MO recovery<br />
PALLIATIVE TREATMENT<br />
Transfusion-related support according to the clinic’s needs<br />
Antibiotic therapy for infectious cases<br />
Palliative Chemotherapy<br />
• Ara – C 40mg/m 2 SC D1 – D4 – according to leukometry<br />
• 6TG 40 mg/m 2 VO continuous – adjustment according to toxicity<br />
PALLIATIVE TREATMENT MUST BE PERFORMED, ESPECIALLY AS OUTPATIENT REGIMEN<br />
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