Protocols - Hemorio

WHO CLASSIFICATION
SUBTYPE PERIPHERAL BLOOD BONE MARROW
REFRACTORY ANEMIA
(AR)
ANEMIA REFRATÁRIA
COM DYSPLASIA
MULTILINHAGEM
(ARDM)
ARSA
ARDM and ring
sideroblasts (ARDM-SA)
AREB – 1
AREB – 2
NON-CLASSIFIED
MYELODISPLASTIC
SYNDROME
SMD associated to Del 5q
alone
IPSS
Anemia;
Without rare blasts
Bi- or pancytopenia;
Without or rare blasts;
Absence of Auer rods;
< 1000 Monocytes
Anemia;
Absence of blasts
Bi- or pancytopenia;
Without or rare blasts;
Absence of Auer rods; < 1000
Monocytes
Cytopenias; < 5% blasts;
Absence of Auer rods;
< 1000 Monocytes
Cytopenias;
5 – 19% de blasts;
Presence or absence of Auer rods;
< 1000 Monocytes
Cytopenias;
With or without blasts;
Absence of Auer rods
Anemia;
< 5% blasts;
Normal platelets or increased
87
Erythroid dysplasia;
< 5% blasts;
10% cells in >2% myeloid line;
< 5% blasts;
15 %
Dysplasia in >10% cells in >2% myeloid line;
>15 % ring sideroblasts;
Absence of Auer rods.
Dysplasia in one or more lines;
5 – 9% blasts;
Absence of Auer rods.
Dysplasia in one or more lines;
10 - 19% blasts;
Presence or absence of Auer rods.
Granulocytic or megakaryocytic dysplasia; <
5% blasts;
Absence of Auer rods;
< 5% blasts; Absence of Auer rods;
Megacariocytes in normal amount or increased
with hypolobulated nucleus;
Del 5q alone.
0 0.5 1.0 1.5 2.0
% BLASTS MO = 2.5 0.2
TREATMENT:
LOW RISK AND INTERMEDIATE RISK 1: