Protocols - Hemorio
Protocols - Hemorio
Protocols - Hemorio
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1 st line Chemotherapy<br />
R- CHOP<br />
(21 days)<br />
Cyclophosphamide 750mg/m 2 EV D1<br />
Doxorubicin 50mg/m 2 EV D1<br />
Oncovin 1.4mg/m 2 (max2mg) EV D1<br />
Prednisone 100mg VO D1 to D5<br />
Rituximab 375mg/m 2 EV D1<br />
G-CSF 24 h after QT in subjects that present neutropenia among the cycles.<br />
2 nd line Chemotherapy – Send to TCTH group to prepare the Self-TCTH<br />
ICE<br />
(21 to 28 days)<br />
ESHAP<br />
(28 days)<br />
Ifosfamide 1g/m 2 in 1h D1 and D2<br />
Etoposide 150mg/m 2 2 x/d (hour 1 to 11 and hour 12 to 24) D1 and D2<br />
Carboplatin 200mg/m 2 in 1h (hour 11 to 12) D1 and D2<br />
Mesna 333mg/m 2 30 min before, 4h and 8h after Ifosfamide<br />
Etoposide 60mg/m 2 EV D1 to D4 – Care with hypotension.<br />
Methylprednisolone 500mg EV D1 to D4<br />
Cytarabine 2g/m 2 in 2 h D5 after the conclusion of Cisplatin<br />
Cisplatin 25mg/m 2 /d IC D1 to D4. Evaluate infusion with Mannitol and proper<br />
hydration<br />
In case of full or partial remission Self-TMO. In case of disease progression, palliative scheme<br />
3 - MANTLE LYMPHOMA<br />
- Conventional cytogenetics or FISH in case of MO committed t (11;14)<br />
- Immunohistochemistry – CD5+, CD20+, CD23-, Cyclin D1+, CD10-/+. Some of them can be CD5- or<br />
CD23+. If the diagnosis is suspected, perform Cyclin D1, associated to FISH t (11;14)<br />
- Lumbar puncture in case of blast variant or neurological symptoms<br />
- EDA in case of Waldeyer ring attack<br />
- Colonoscopy<br />
- If candidate to TMO (P S
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