Protocols - Hemorio

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- Leukemia / T-Cell Lymphoma in Adult (HTLV1+) - Extranodal T/NK Lymphoma, Nasal Type - T-Lymphoma Enteropathy type - T-Lymphoma Hepatosplenic - Skin Panniculitis T-like Lymphoma - Fungoid Mycosis / Sézary Syndrome - Anaplastic Big Cells Lymphoma, T/null, Skin primary type - Anaplastic Big Cells Lymphoma, T/null, Systemic primary type - Peripheral T-Lymphoma - Angioimmunoblastic T-Lymphoma 1 – FOLLICULAR LYMPHOMA Conventional cytogenetics or FISH - t (14;18) Immunohistochemistry – CD10+, bcl-2+, CD23+/-, CD43-, CD5-, CD20+, Cyclin D1-. Rare cases may be CD10-, bcl-2 -. STAGING Stage Involvement Area I Only Lymph nodes group II Multiple groups of lymph nodes at the same side of diaphragm III Multiple groups of lymph nodes in both sides of diaphragm IV Multiple extranodal sites or lymph nodes and extranodal disease X Bulk > 10 cm E Extranodal extension or an only isolated site of extranodal disease A/B B Symptoms: weight loss>10%, fever, nocturnal sweating PROGNOSIS – FLIPI CRITERION Age > 60 years old Stage Ann Arbor III - IV Hemoglobin Level < 12 g/dl LDH > upper limit Number of nodal sites > 4 Risk Group Factors Number Low 0 - 1 Intermediate 2 High > or = 3 128
TREATMENT Follicular LNH Stage I and II RXT or QT followed by RXT RC or RP No response Follow-up Progression Protocol stages III and IV 129 Protocol stages III and IV Stage III Abdominal bulky, III and IV Indication to treatment* With no indication RXT (if palliative for symptomatic) or QT Follow-up RC or RP With no response or progression Progression Follow-up With no QT indication 2 nd line Diffuse LNH Protocol Progression If QT indication 2 nd line
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PROTOCOLS INSTITUTE OF HAEMATOLOGY
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COORDINATION AND REVISION Clarisse
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SUMMARY: PART I - CLINICAL PROTOCOL
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1.INICIAL CLINICAL EVALUATION SICKL
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TREATMENTO AND IN ADULTS AT ANY AGE
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SPLENECTOMY - INDICATIONS: (1) CHIL
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OUTPATIENT TREATMENT: It is based o
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ASPIRIN AND NSAID PARACETAMOL OPIOI
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CONDUCTION: - Hospitalization - Com
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ONE, TWO-DIMENSIONAL DOPPLER ECHOCA
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Hemianopsia Homonymous deficit of v
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TREATMENT OF CONVULSIVE EPISODES -
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INITIAL ATTENDANCE TO PREGNANT WOME
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- It may occurs acute thoracic synd
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3 Diet with potassium restriction 4
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MICROALBUMINURIA Screening Patients
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RECURRENCE OF PRIAPISM: - Pain Trea
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SPECIAL CARES DEFERASIROX - The use
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TREATAMENT: DRUG Hydroxiurea (hard
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MAJOR AND INTERMIDIATE THALASSEMIA
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HEREDIRATY SPHEROCYTOSIS CLINICAL E
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G6PD DEFICIENCY INITIAL EVALUATION
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LABS EXAMS TO DIAGNOSE APLASTIC ANE
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SELFIMMUNE HEMOLYTIC ANEMIA CONCEPT
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2. Splenectomy: Vaccinate 14 days b
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IMMUNE THROMBOCYTOPENIC PURPURA LAB
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THROMBOTIC THROMBOCYTOPENIC PURPURA
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HEMORRHAGIC SYNDROME INTRODUCTION H
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MULTIDISCIPLINARY FOLLOW-UP OF HEMO
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LYOPHILIZED CONCENTRATES: They are
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TABLE 2: REPLACEMENT THERAPY TO PER
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CONDUCTION IN CONFIRMED INTRACRANIA
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Severe CET with neurological change
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PHARMACOKINETICS OF CLOTTING FACTOR
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INHIBITORS CLASSIFICATION The inhib
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- Extended surgeries require increa
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CLINICAL DIAGNOSIS: According to In
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DDAVP TEST The “test dose” must
Page 78 and 79: TREATMENT OF BLEEDING SITUATIONS SI
Page 80 and 81: TABLE 6 - REPLACEMENT THERAPY IN LE
Page 82 and 83: • Primary prophylaxis: controvers
Page 84 and 85: CLINICAL AND LABORATORIAL FOLLOW-UP
Page 86 and 87: MYELODISPLASIC SYNDROME LABORATORIA
Page 88 and 89: If EPO < 500 mU/ml : EPO (8000U 3x/
Page 90 and 91: ACUTE MYELOID LEUKEMIA LABORATORIAL
Page 92 and 93: LMA LMA M3 - non-M3 LMA Protocol LM
Page 94 and 95: Key: Volunteer to aggressive treatm
Page 96 and 97: Acute Promyelocytic Leukemia Transf
Page 98 and 99: BMP LMA IN CHILDREN AND TEENAGERS
Page 100 and 101: Ara-c dose reduction by age: Age in
Page 102 and 103: ATRA RECOMMENDATION: ATRA is starte
Page 104 and 105: - venous hydration - leukapheresis
Page 106 and 107: POLYCYTHEMIA VERA LABORATORIAL TEST
Page 108 and 109: TREATMENT - 2nd LINE - Indicated fo
Page 110 and 111: ACUTE LYMPHOID LEUKEMIA LABORATORIA
Page 112 and 113: RE-INDUCTION Phase I (weeks 1-4) -
Page 114 and 115: Cycles 2, 4, 6, 8 - Methotrexate 20
Page 116 and 117: PHASE 2 Infusion CPM in 1 hour 1000
Page 118 and 119: CURATIVE RADIOTHERAPY of CNS < 1 ye
Page 120 and 121: CHRONIC LYMPHOCYTIC LEUKEMIA LABORA
Page 122 and 123: fludarabine 25 mg/m VENOUS 2 D1-D3
Page 124 and 125: TRICHOLEUKEMIA LABORATORIAL TESTS -
Page 126 and 127: - age >45 years old - leukocytosis
Page 130 and 131: INDICATIONS FOR THE TREATMENT: Symp
Page 132 and 133: 1 st line Chemotherapy R- CHOP (21
Page 134 and 135: CODOX- M/IVAC Cycles 1 and 3 Cyclop
Page 136 and 137: BLOCK A DEXA VO/IV 10 mg /m2 in 3 d
Page 138 and 139: - Surgical treatment is only indica
Page 140 and 141: LEUKEMIA / T-CELLS LYMPHOMA OF THE
Page 142 and 143: HN2 or PUVA (similar to the located
Page 144 and 145: MULTIPLE MYELOMA LABORATORIAL TESTS
Page 146 and 147: RESPONSE CRITERIA Full Response Abs
Page 148 and 149: WALDENSTRON MACROGLOBULINEMIA LABOR
Page 150 and 151: − If HLA-identical related donor
Page 152 and 153: TREATMENT PROTOCOL - ACUTE MYELOID
Page 154 and 155: TREATMENT PROTOCOL - MULTIPLE MYELO
Page 156 and 157: Post-autologous transplantation pro
Page 158 and 159: PART II - TRANSFUSIONAL PROTOCOLS A
Page 160 and 161: PRESERVATION AND CONSERVATION: The
Page 162 and 163: TRANSFUSION OF RED BLOOD CELLS, PLA
Page 164 and 165: FORMAL CONTRAINDICATIONS TO THE PLA
Page 166 and 167: 1 - TRANSFUSION OF FROZEN FRESH PLA
Page 168 and 169: COMMUNICATION FORM OF CRYOPRECIPITA
Page 170 and 171: Volume to be = changed (*) VOLEMIA
Page 172 and 173: HEMOTHERAPIC PROTOCOL TO FALCIFORM
Page 174 and 175: 5 - TRANSFUSIONAL CONDUCT AT THE SE
Page 176 and 177: CML - Subjects with symptoms relate
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- Aplastic anemia bearers - HIV pos
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Severe reaction: anaphylactic shock
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- Heart monitoring - Prescribe Furo
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CARES AT THE PLATELETS CONCENTRATE
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ATTACHMENT I - HEMATOLOGICAL CLINIC
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INFECTIOUS SPLENO MEGALIES IMMUNO L
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INVESTIGATION OF HEMORRHAGIC SYNDRO
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INVESTIGATION OF POLYGLOBULIAS: POL
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ATTACHMENT III - HEMATOLOGY SPECIAL
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IMMUNOPHENOTYPE PROFILE OF THE ACUT
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ATTACHMENT IV - PAIN APPROACH ROUTI
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If it is prescribed for more than 1
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HOW TO PRESCRIBE OPIOID: SPECIAL CA
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SPECIFICITIES OF EACH OPIATE (cont
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METHADONE Intravenous (*) Oral path
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Psychic Dependence or “addiction
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CROSS TOLERANCE - The subject must
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ATTACHMENT V - CHEMOTHERAPY SUBJECT
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ATTACHMENT VII - IRON CHELATION GEN
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10. G N N - DFP DFP-100 mg/kg/day d
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ATTACHMENT VIII - SEDATION IN CHILD
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224 NOTES _________________________
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224 NOTES _________________________
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Expresso Gráfica e Editora Ltda-me
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Protocols - Hemorio

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