Protocols - Hemorio

TRICHOLEUKEMIA
LABORATORIAL TESTS
- Full hemogram with reticulocytes and hematoscopy of peripheral blood
- Full biochemistry with hepatogram
- Immunophenotype of peripheral blood
- Cytochemistry of SP (acid phosphates resistant to tartrate +)
- Bone marrow aspirated -> usually dry
- Bone marrow biopsy with immunohistochemistry
- Positive markers that differentiate from other B-lymphoproliferative diseases: CD11c, CD105, CD25
TREATMENT
- 1 st CHOICE: Cladribine 0.1mg/kg/day/7 days continuous infusion. Repeat after 6 months in case of
absence of remission with the 1 st cycle
- The subjects must receive prophylaxis to PCP with Bactrim up to 6 months after the conclusion of the
treatment. Discontinue Bactrim during the days of cladribine infusion.
RELAPSE / OPTIONS
- Retreatment with the initial scheme
- Usage of other purine analogous (e.g.: pentostatin)
- INF
- Rituximab
- Consider splenectomy only in cases of symptomatic bulky splenomegaly, with no response to the drug
treatment
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