Protocols - Hemorio

LLA SUBJECT OVER 60 YEARS OLD: CALGB
INDUCTION
Cyclophosphamide EV 800 mg/m 2 D 1
Daunorubicin EV 30 mg/m 2 D 1-3
Vincristine EV 2 mg D 1, 8, 15, 22
Prednisone VO 60 mg/m 2 /d D 1-7
L-asparaginase IM 6000 IU/m 2 Days 5, 8, 11, 15, 18, 22
G-CSF 5 ug/kg SC / d from D4 until neutrophils >1000/uL in 2 consecutive determinations
COURSE IIA: EARLY INTENSIFICATION
(4 weeks; repeat once the same cycle – Course IIB more 4 weeks)
Methotrexate IT 15 mg D 1
Cyclophosphamide IV 1000 mg/m 2 D 1
6-mercaptopurine VO 60 mg/m 2 /d D 1-14
Cytarabine SC 75 mg/m 2 /d D 1-4, 8-11
Vincristine IV 2 mg D 15, 22
L-asparaginase IM 6000 IU/m 2 D 15, 18, 22, 25
COURSE III: CNS PROPHYLAXIS AND MAINTENANCE (12 WEEKS)
Cranial Radiation 2400 cGy D 1-12
Methotrexate IT 15 mg D 1, 8, 15, 22, 29
6-mercaptopurine VO 60 mg/m 2 /d D 1-70
Methotrexate VO 20 mg/m 2 D 36, 43, 50, 57, 64
COURSE IV: LATE INTENSIFICATION (8 WEEKS)
Doxorubicin IV 30 mg/m 2 D 1, 8, 15
Vincristine IV 2 mg D 1, 8, 15
Dexamethasone VO 10 mg/m 2 /d D 1-14
Cyclophosphamide IV 1000 mg/m 2 D 29
6-Thioguanine VO 60 mg/m 2 /d D 29-42
Cytarabine SC 75 mg/m 2 /d D 29-32, 36-39
COURSE V: EXTENDED MAINTENANCE (UNTIL 24 MONTHS AFTER THE DIAGNOSIS)
Vincristine IV 2 mg D 1 every 4 weeks
Prednisone VO 60 mg/m 2 /d D 1-5 every 4 weeks
6-mercaptopurine VO 20 mg/m 2 /d D 1-28
Methotrexate VO 20 mg/m 2 D 1, 8, 15, 22
RELAPSE LLA ( 2 nd Line )
Relapse over 2 years after the diagnosis, the same treatment scheme can be used
Early relapse: with the purpose to send to the allogenic TMO related or not (REREME)
Protocol HiperCVAD
Cycles 1, 3, 5, 7
- Cyclophosphamide 300mg/m 2 in 2h every 12h D1 to D3. Total 6 doses
Mesna 600mg/m 2 IC D1 to D3. Start 1h before the 1 st dose until 12h after the last dose of
cyclophosphamide
- Oncovin 2mg EV D4 and D11
- Doxorubicin 50mg/m 2 EV D4
- Dexamethasone 40mg EV or VO D1 to 4 and D11 to 14
113