Protocols - Hemorio

Validity – 24 months, if it is kept at a temperature of -30 o C or below and 12 months, if it is kept at a
temperature between -20 o C and 30 o C.
SELECTION AND PREPARATION: PFC must be ABO-compatible to the receptor red blood cells. It must
be defrozed at a temperature of 37 o C and infused immediately.
The volume to be transfused is determined by the body surface of the subject and by the clinical condition.
In general, 5 to 20 ml/Kg is used.
The PFC transfused to correct changes of clotting must make the fibrinogen levels normal and take the
TAP (prothrombine time) and TTP (activated partial thromboplastin time) to hemostatic standards.
Therapeutic dosage of PF to be administered at the coagulopathies is 10 to 20ml/kg, taking into account
the clinical setting and the base disease of the subject. The frequency of administration depends on the
mean life of each factor to be restored.
INDICATIONS: The plasma transfusion is indicated in the following situations:
Presence of hemorrhage associated to the documented coagulopathy (TAP and/or TTP> 1.5).
Prophylactically in subjects that will undergo invasive procedures and have coagulopathy (TAP and/or
TTP> 1.5)
Subjects with hemorrhage and deficiency of Factor V or Factor XIII.
CONTRAINDICATIONS: Do not use PFC as a repository of blood volume. Do not use for coagulopathies
that may be corrected by Vit. K.
5 - CRYOPRECIPITATE:
DESCRIPTION: A unit of cryoprecipitate is prepared unfrozing a unit of PFC between 2 o C and 6 o C and
recovering the cold-insoluble precipitate, that remains settled at the bottom of the bag. This cryoprecipitate
must be refrozed in 1 hour. It contains: fibrinogen; Factor VIII: C; Factor VIII:vWF (von Willebrand factor);
Factor XIII and fibronectin. Each unit must contain at least 70 IU Factor VIII:C and 140 mg of fibrinogen in
15 ml of plasma. The cryoprecipitate is transfused in “pool” of a plenty of units.
PRESERVATION AND CONSERVATION: The anticoagulant is the same as the source bag and its
validity varies according to the conservation temperature.
- (–) 30 o C or below, the validity is 24 months
- (–) 20 o C and (–) 30 o C, the validity is 12 months.
SELECTION AND PREPARATION: Preferably the transfusion must be ABO-compatible such as PFC.
For the transfusion in children, it must be isogroup. It must be defrozed at 37 o C and infused immediately.
INDICATIONS: The transfusion of cryoprecipitate is indicated whenever there is a hemorrhage, and a
decrease of Fibrinogen below 10 mg/dL. In addition, the cryoprecipitate is indicated for the treatment of
subjects with hemorrhage by deficit of Factor XIII, when there is not, under any circumstances, the
concentrate of industrial factor VIII, available for use.
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