here - Australian College of Veterinary Scientists
here - Australian College of Veterinary Scientists
here - Australian College of Veterinary Scientists
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The allergens used for equine skin testing tend to be the same that is used for small<br />
animal testing, and <strong>of</strong>ten allergen selection has occurred with small animals in mind.<br />
Additional horse-specific allergens such as Culicoides are also included for the equine<br />
tests. W<strong>here</strong> horses are housed in the same metropolitan area, it is assumed that<br />
exposure to similar allergens as small animals will occur. However, modifications to<br />
the allergen selection may be necessary for horses from more distant country areas.<br />
It is not apparent whether particular allergens are relevant in horses, as their lifestyle<br />
may prevent significant exposure to various substances; such as insects (cockroach),<br />
House-dust mites and pollens from fodder materials brought into the area rather than<br />
grown in the area. Testing with epithelia (from other animals and humans) is not<br />
possible in Australia due to quarantine regulation against the importation <strong>of</strong> such<br />
allergens, so the significance <strong>of</strong> these is unknown in the <strong>Australian</strong> context. In one<br />
study in affected horses, positive intradermal test reactions to epithelia were seen in a<br />
significant number <strong>of</strong> clinically affected horses (54.2% to human dander!)(2).<br />
Allergen mixes are available, but testing with these is not recommended (1), as the<br />
concentration <strong>of</strong> the individual allergens in the mix becomes too dilute for detection.<br />
Variation in species <strong>of</strong> insect and pollen allergens may also be important. The<br />
Culicoides extract available through Greer laboratories is derived from Culicoides<br />
nebiculosis. In Australia, Culicoides brevitarsis is considered to be the only relevant species<br />
<strong>of</strong> Culicoides (at least in NSW, according to entomologists at the Elizabeth Macarthur<br />
Agricultural Institute - pers comm.). Information from Greer suggests that crossreactivity<br />
across most species <strong>of</strong> Culicoides can be expected, but the reality <strong>of</strong> this<br />
assumption is not known.<br />
20<br />
ACVSC Proceedings Dermatology Chapter Science Week 2005