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Erythema multiforme<br />

Rare, acute, self-limiting, urticarial, maculopapular or vesico-bullous dermatosis. Other<br />

triggering influences such as drugs, infections (especially Herpes virus), and tumours -<br />

especially lymphoreticular neoplasms. Many cases are classified as idiopathic.<br />

Aetiology / Pathophysiology<br />

Can be considered a type <strong>of</strong> allergic response, being very similar to graft versus host<br />

reaction.<br />

Clinical presentation<br />

Lesions tend to have a symmetrical distribution. Asymptomatic cutaneous eruptions.<br />

Characteristic 'donut like' skin urticarial lesions develop rapidly from initial urticaria and<br />

plaques. Occasionally involves mucous membranes <strong>of</strong> mouth. Persist from days to<br />

weeks. No scaling, crusting or alopecia in many horses. These plaques do not pit on<br />

pressure<br />

Differential diagnosis<br />

Urticaria, amyloidosis, mastocytoma, lymphosarcoma, fixed drug reaction, toxic<br />

epidermal necrolysis.<br />

Diagnosis<br />

Skin biopsy.<br />

Management<br />

Runs benign course over 2-3 months. Recurrence reported in some cases.<br />

Prognosis<br />

Guarded to poor for permanent recovery.<br />

46<br />

ACVSC Proceedings Dermatology Chapter Science Week 2005

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