2010 AnnuAl REpoRT - Ciberdem

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Ayuso E, Mingozzi F, Bosch F Curr Gene Ther, 10, 423-436 (2010) IF: 4.852 first quartile. With other international groups Skeletal muscle metabolism in the pathology and treatment of type 1 diabetes Mann CJ, Ayuso E, Anguela XM, Bosch F Curr Pharm Des, 16, 1002-1020 (2010) IF: 4.414 first quartile Research grants European projects Identification of the genes regulated by the SIRT1 histone deacetylase and their contribution in the pathogenesis of type 2 diabetes and obesity EU, Marie Curie International Reintegration Grant, MIRG- CT-2007-207745: 2008-2012 Principal Investigator: Efrén Riu Analysis of a new pathway to import iron into the retina: role of ferritin as iron carrier and implications in radical detoxification FCT Fundaçao para a ciência e a tecnologia. Ministério da ciência, tecnologia e ensino superior Portugal, PTDC/SAU-ORG/110856/2009: 2010-2012 Principal Investigator: Jesús Ruberte INFRAFRONTIER. The European Infrastructure for phenotyping, archiving and dissemination of disease models EU, European Strategy Forum on Research Infrastructures, FP7-INFRA-STRUCTURES-2007-1: 2008-2012 Principal Investigator: Fàtima Bosch Coordinator: Martin Hrabé d’Angelis EUMODIC. The European Mouse Disease Clinic. A distributed phenotyping resource for studying human disease EU, Integrated Project FP6-2005-LIFESCIHEALTH-6, LSHG- CT-2006-037188: 2007-2011 Principal Investigator: Fàtima Bosch Coordinator: Steve Brown CLINIGENE. European Network for the Advancement of Clinical Gene Transfer and Therapy EU, Network of Excellence, FP6-2004-LIFESCIHEALTH-5, LSHB-CT-2006-018933: 2006-2011 Principal Investigator: Fàtima Bosch Coordinator: Odile Cohen-Haguenauer National projects Estudio del papel de los leucotrienos en el desarrollo de la resistencia a la insulina y aterosclerosis asociadas a la obesidad Instituto de Salud Carlos III, PI07/0313: 2007-2010 Principal Investigator: Sylvie Franckhauser Neuropatía Diabética: estudio de la expresión génica en la degeneración y posterior regeneración nerviosa en un modelo murino transgénico RIP/IFNbeta Ministerio de Educación y Ciencia, PI 05/0892: 2008-2010 Principal Investigator: Martí Pumarola Atlas morfológico para el fenotipado de ratones mutantes Ministerio de Ciencia e Innovación, SAF2008-0581-E: 2009-2011 Principal Investigator: Jesús Ruberte Estudio del efecto de la deacetilación de cromatina por miembros de la familia de las sirtuinas en la patogénesis de la resistencia a la insulina y diabetes tipo 2 Ministerio de Ciencia e Innovación, SAF2008- 03083: 2009-2011 Principal Investigator: Efrén Riu Estudio del papel de los factores de crecimiento similares a la insulina en la regeneracion de la celula ß pancreática Ministerio de Educación y Ciencia, SAF2008-00962: 2009-2011 Principal Investigator: Fàtima Bosch Desarrollo de vectores adeno-asociados (AAV) para la terapia neuroprotectora en enfermedades degenerativas de la retina Proyectos TRACER, Ministerio de Ciencia e Innovación en colaboración con ProRetina Therapeutics SL, PET2008_0282_02: 2009-2011 Principal Investigators: Enrique de la Rosa, Fàtima Bosch With other CIBERs: CIBERER Senescencia celular en los vasos sanguíneos de la retina: implicaciones de P16 en el cross-linking enzimático del colágeno de la membrana basal durante el envejecimiento Instituto de Salud Carlos III, PS09/01152: 2010-2013 Principal Investigator: Jesús Ruberte Generación de una librería AAV-CRE para la obtención de ratones mutantes condicionales Ministerio de Educación y Ciencia, SAF2010-10507-E: 2010-2012 Principal Investigator: Fàtima Bosch Autonomous Community project Ajut per a grups de recerca consolidats Agència de Gestió d´Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya, SGR 224: 2009-2013 Principal Investigator: Fàtima Bosch Patents European patents Telomerase reverse transcriptase for protection against ageing 2010 Annual Report 99
Patent application number: EP10168341.5 Priority country: Europe Priority date: July 2, 2010 Inventors: M Antonia Blasco, Bruno Bernardes, Fàtima Bosch, Eduard Ayuso Universitat Autònoma de Barcelona and Centro Nacional de Investigaciones Oncológicas Gene Therapy composition for use in diabetes treatment Patent application number: EP10169309.1 Priority country: Europe Priority date: July 12, 2010 Inventors: Fàtima Bosch, Eduard Ayuso, David Callejas Universitat Autònoma de Barcelona PhD theses A study of the role of VEGF overexpression in adipose tissue in diet-induced obesity and insulin resistance Author: Ivet Elias Puigdomènech Thesis advisors: Fàtima Bosch, Sylvie Franckhauser University: Universitat Autònoma de Barcelona Thesis defense date: December 15, 2010 ■ 100 CibeRdem
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2010 Annual Report CIBERDEM Centro
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Letter from the Scientific Director
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Contents Prologue Research results
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Research results Publications In 20
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Project management Introduction The
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Training programme Introduction The
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Outreach activities CIBERDEM Fundra
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More about CIBERDEM The Centro de I
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Human Resources In 2010, CIBERDEM h
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Transversal projects Di@bet.es Stud
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Di@bet.es Study Introduction Attemp
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CIBERDEM Projects Introduction CIBE
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girls (girls born small for gestati
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Biobank Introduction and objectives
Page 30 and 31:
Metabolomics Platform Introduction
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Area 1 Insulin signalling and resis
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Diabetes and cardiovascular Faculta
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Metabolomics Platform Universitat R
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Obesity, inflammation and insulin r
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Mechanisms of control of glucose an
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Metabolic engineering and diabetes
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Molecular mechanisms of insulin res
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Molecular characteristics, and acti
Page 49 and 50: Heterogenic and polygenic diseases.
Page 51: Principal Investigator: Antonio Zor
Page 54 and 55: The research activity of this area
Page 56 and 57: The cationic cluster of group IVA p
Page 58 and 59: agent that affects the enterohepati
Page 60 and 61: Dyslipidaemia, inflammation and end
Page 62 and 63: Daño orgánico en la diabetes mell
Page 64 and 65: Proteomic analysis of plasma in the
Page 66 and 67: Prenatal growth restriction and sub
Page 68 and 69: The effects of metformin on cardiov
Page 70 and 71: Lipids and Arteriosclerosis Researc
Page 72 and 73: Review Pitavastatin - from clinical
Page 74 and 75: Diabetobe Hospital Clínico San Car
Page 76 and 77: Scientific collaborations within CI
Page 78 and 79: Atherosclerosis, 209, 201-205 (2010
Page 80 and 81: Solvay, SA: 2008-2010 Principal Inv
Page 82 and 83: Endocrinology and Nutrition Service
Page 84 and 85: Prevención de la Diabetes mellitus
Page 86 and 87: Pharmacological targets in inflamma
Page 88 and 89: Diabetes and Metabolic Associated D
Page 90 and 91: Autonomous Community project Grup d
Page 92 and 93: Area 3 of CIBERDEM comprises thirte
Page 94 and 95: Escrivá F, Alvarez C J Mol Endocri
Page 96 and 97: Am J Physiol Endocrinol Metab, 298,
Page 98 and 99: Transgenic animal models and gene t
Page 102 and 103: Laboratory of Molecular Endocrinolo
Page 104 and 105: Hospital de Cruces Diabetes Researc
Page 106 and 107: Research grants International proje
Page 108 and 109: Proinsulin and tyrosine hydroxilase
Page 110 and 111: Genomic programming of beta cells I
Page 112 and 113: Diabetes and obesity: biopathology
Page 114 and 115: Utilidad de la ecografía arterial
Page 116 and 117: Islet cell and stem cell physiology
Page 118 and 119: in diabetic patients with chronic c
Page 120 and 121: Liraglutide versus sitagliptin for
Page 122 and 123: Unit of Cell Physiology and Nutriti
Page 124 and 125: National projects Efectos a corto y
Page 126 and 127: Altirriba J, Gasa R, Casas S, Ramí
Page 128 and 129: Transcriptional mechanisms of pancr
Page 131 and 132: Epilogue
Page 133 and 134: Keyword index* Beta-cell signal tra
Page 135 and 136: Association of selected ABC gene fa
Page 137 and 138: Leiter LA, Levitt NS, Mareev V, Mar
Page 139 and 140: Low body adiposity and high leptine
Page 141 and 142: Alvaro A, Rosales R, Masana L, Vall
Page 143 and 144: The apolipoprotein A5 (APOA5) gene
Page 145 and 146: www.ciberdem.org/annualreport CIBER
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