2010 AnnuAl REpoRT - Ciberdem

Molecular characteristics, and action of incretins,
in the physiopathology of glucose, lipids and
bone metabolism
Fundación Jiménez Díaz, Madrid
www.fjd.es
Principal Investigator María Luisa Villanueva Peñacarrillo mlvillanueva@fjd.es Associate researchers Nieves González, Isabel Valverde,
Alicia Acitores, Bernardo Nuche Berenguer Predoctoral students Irene Gutiérrez, Paola Moreno, Irene Ramos
Research grants: 3
National projects: 2
Private funds: 1
Scientific collaborations within CIBERDEM: 1
PhD theses: 1
Awards: 1
Keywords
Glucose transport. Hormone receptors. Incretins. Insulin
sensitivity and resistance. Lipid metabolism.
Main lines of research
-The effects and mechanisms in the action of GLP-1 action
(glucagon-like-peptide 1) -an incretin with antidiabetic
properties - and also that of GLP-1-homologue peptides,
on glucose, lipids and bone metabolism.
-The mechanism of insulin secretion.
-The genetic characteristics, pharmacology and function
of the human BRS-3 receptor, a possible target for the
treatment of diabetes and obesity.
-The effect of amylin on glucose metabolism.
Research grants
National projects
The genetic characteristics, pharmacology and function
of the human BRS-3 receptor, a possible target for the
treatment of diabetes and obesity
Instituto de Salud Carlos III (ISCIII), FIS CP08/00158: 2009-
2011
Principal Investigator: Nieves González Gómez
A molecular characterization of GLP-1 receptor in
extrapancreatic tissues
Instituto de Salud Carlos III (ISCIII), PS09/01185: 2010-
2012
Principal Investigator: Nieves González Gómez
Associate investigators: ML Villanueva Peñacarrillo, Irene
Ramos Álvarez, Irene Gutiérrez Rojas
46 CibeRdem