Treatment of polycystic ovary syndrome (PCOS) with metformin ameliorates insulin resistance in parallel with the decrease of serum interleukin-6 concentrations Luque-Ramírez M, Escobar-Morreale HF Horm Metab Res, 42, 815-820 (<strong>2010</strong>) Tumor necrosis-like weak inducer of apoptosis as a proinflammatory cytokine in human adipocyte cells: up-regulation in severe obesity is mediated by inflammation but not hypoxia Vendrell J, Maymó-Masip E, Tinahones F, García-España A, Megia A, Caubet E, García-Fuentes E, Chacón MR J Clin Endocrinol Metab, 95, 2983-2992 (<strong>2010</strong>) Type 2 diabetes impairs pulmonary function in morbidly obese women: a case-control study Lecube A, Sampol G, Muñoz X, Hernández C, Mesa J, Simó R Diabetologia, 53, 1210-1216 (<strong>2010</strong>) Weight loss in prepubertal obese children is associated with a decrease in adipocyte fatty-acid-binding protein without changes in lipocalin-2: a 2-year longitudinal study Corripio R, Gónzalez-Clemente JM, Pérez-Sánchez J, Näf S, Gallart L, Nosàs R, Vendrell J, Caixàs A Eur J Endocrinol, 163, 887-893 (<strong>2010</strong>) WWOX gene is associated with HDL cholesterol and triglyceride levels Sáez ME, González-Pérez A, Martínez-Larrad MT, Gayán J, Real LM, Serrano-Ríos M, Ruiz A BMC Med Genet, 11, 148 (<strong>2010</strong>) <strong>2010</strong> Annual Report 143
www.ciberdem.org/annualreport CIBERDEM Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders Scientific Director Ramon Gomis Adjunct Scientific Director Anna Novials Steering Committee Ramon Gomis, Anna Novials, Manuel Benito, Rafael Carmena, Fàtima Bosch, Antonio Zorzano Management Office Managing Director | Ana Bosch Executive Secretary | Tania Fernández Human Resources and Legal Manager | Libertad Montaño Project Manager | Gemma Pascual Knowledge Management and Communication | Marta Vidal Fundraising and Marketing | Johanna Rivera Proposal Writer | Donald Mc Donagh Accounting Agent | Antonio Santaliestra Purchase Agent | Sebastián Montaño Administrative Assistant | Maria Rosa Vázquez Contact details | Bonanova 69, 6th floor, 08017 Barcelona, Spain, info@ciberdem.org An initiative of ISCIII Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Gobierno de España Iniciativa Ingenio <strong>2010</strong>, programa Consolider, Acciones CIBER VI Plan Nacional de I+D+i 2008-2011 Institutions of the Consortium BIOEF (Fundación Vasca de Innovación e Investigación Sanitarias), CIPF (Fundación Centro de Investigación Príncipe Felipe), CSIC (Consejo Superior de Investigaciones Científicas), FIHCUV (Fundación Investigación Hospital Clínico Universitario de Valencia), FIR-HUVH (Fundació Institut de Recerca Hospital Universitari Vall d’Hebron), FJD (Fundación Jiménez Díaz), FSJD (Fundació Sant Joan de Déu), IDIBAPS (Institut d’Investigacions Biomèdiques August Pi i Sunyer), IDIBELL (Fundació Institut d’Investigació Biomèdica de Bellvitge), IISPV (Fundació Institut d’Investigació Sanitària Pere Virgili), IMABIS (Fundación Instituto Mediterráneo para el Avance de la Biotecnología y la Investigación Sanitaria), IRB (Fundació Institut de Recerca Biomèdica), IRHSCSP (Institut de Recerca Hospital de la Santa Creu i Sant Pau), SERMAS (Servicio Madrileño de Salud), UAB (Universitat Autònoma de Barcelona), UB (Universitat de Barcelona), UCM (Universidad Complutense de Madrid), UMH (Universidad Miguel Hernández), UPO (Universidad Pablo de Olavide) 2011 CIBERDEM Edition | CIBERDEM Management Office Director | Ramon Gomis Editor | Marta Vidal Designer | Octavi Rodríguez Language Consultant | Andrew Hastings Texts | CIBERDEM Research Groups and CIBERDEM Management Office Images and Graphics | Manuel Acosta, Verónica Alba, Gemma Alberich, Carmen Álvarez, David Álvarez, Elvira Álvarez, Francesc Avia, María Ángeles Balboa, Jesús Balsinde, Alberto Bartolomé, Francisco Blanco Vaca, Enrique Blázquez, Fàtima Bosch Group, Laura Brugnara, Ernesto Caballero, Ivan Caravaca, Manuel Carrasco, Xavier Correig, Adelaida Díaz, Héctor F Escobar Morreale, Arturo Fernández, Raimon Ferré, Mónica Fontela, Lucía García, Intza Garin, Ramon Gomis Group, Irene Gutiérrez, Hospital de Cruces, Hospital Universitari de Bellvitge, Verónica Hurtado, Lourdes Ibáñez, María Rosa Insenser, IRB Barcelona, Miguel Ángel Maestro, Roger Mallol, María Luisa Mansego, Franz Martín, Ángela Martínez Valverde, Isabel Martorell, Metabolomics Platform, Mercedes Miranda, Sonsoles Morcillo, Paola Moreno, Emma Mormeneo, Juan Pablo Muñoz, Luke Noon, Katerina Papageorgiou, Vanessa Prensa, Johanna Rivera, Octavi Rodríguez, Anabel Rojas, Gemma Rojo, Isabel Roncero, Susana Ros, José Luis San Millán, Beatriz Sánchez, María del Carmen Sanz, Manuel Serrano Ríos, Noèlia Téllez, Ricardo Uña, Mario Vallejo, Manuel Vázquez Carrera, Patricia Vázquez, Marta Villarroel, Maria Vinaixa, Carina Zabena Cover image | Ana B Ropero by CIBERDEM 3-D reconstruction of a pancreatic islet of Langerhans loaded with the calcium-sensitive dye, Fluo-4. Blue color indicates low intracellular calcium concentration, while orange and yellow indicate high calcium. http://creativecommons.org/licenses/by-nc-nd/3.0 Special thanks to all those individuals and institutions without whose cooperation and good will this book would not have been possible.
- Page 1 and 2:
2010 Annual Report CIBERDEM Centro
- Page 4 and 5:
Letter from the Scientific Director
- Page 6 and 7:
Contents Prologue Research results
- Page 8 and 9:
Research results Publications In 20
- Page 10 and 11:
Project management Introduction The
- Page 12 and 13:
Training programme Introduction The
- Page 14 and 15:
Outreach activities CIBERDEM Fundra
- Page 16 and 17:
More about CIBERDEM The Centro de I
- Page 18 and 19:
Human Resources In 2010, CIBERDEM h
- Page 20 and 21:
Transversal projects Di@bet.es Stud
- Page 22 and 23:
Di@bet.es Study Introduction Attemp
- Page 24 and 25:
CIBERDEM Projects Introduction CIBE
- Page 26 and 27:
girls (girls born small for gestati
- Page 28 and 29:
Biobank Introduction and objectives
- Page 30 and 31:
Metabolomics Platform Introduction
- Page 33 and 34:
Area 1 Insulin signalling and resis
- Page 35 and 36:
Diabetes and cardiovascular Faculta
- Page 37 and 38:
Metabolomics Platform Universitat R
- Page 39 and 40:
Obesity, inflammation and insulin r
- Page 41 and 42:
Mechanisms of control of glucose an
- Page 43 and 44:
Metabolic engineering and diabetes
- Page 45 and 46:
Molecular mechanisms of insulin res
- Page 47 and 48:
Molecular characteristics, and acti
- Page 49 and 50:
Heterogenic and polygenic diseases.
- Page 51:
Principal Investigator: Antonio Zor
- Page 54 and 55:
The research activity of this area
- Page 56 and 57:
The cationic cluster of group IVA p
- Page 58 and 59:
agent that affects the enterohepati
- Page 60 and 61:
Dyslipidaemia, inflammation and end
- Page 62 and 63:
Daño orgánico en la diabetes mell
- Page 64 and 65:
Proteomic analysis of plasma in the
- Page 66 and 67:
Prenatal growth restriction and sub
- Page 68 and 69:
The effects of metformin on cardiov
- Page 70 and 71:
Lipids and Arteriosclerosis Researc
- Page 72 and 73:
Review Pitavastatin - from clinical
- Page 74 and 75:
Diabetobe Hospital Clínico San Car
- Page 76 and 77:
Scientific collaborations within CI
- Page 78 and 79:
Atherosclerosis, 209, 201-205 (2010
- Page 80 and 81:
Solvay, SA: 2008-2010 Principal Inv
- Page 82 and 83:
Endocrinology and Nutrition Service
- Page 84 and 85:
Prevención de la Diabetes mellitus
- Page 86 and 87:
Pharmacological targets in inflamma
- Page 88 and 89:
Diabetes and Metabolic Associated D
- Page 90 and 91:
Autonomous Community project Grup d
- Page 92 and 93:
Area 3 of CIBERDEM comprises thirte
- Page 94 and 95: Escrivá F, Alvarez C J Mol Endocri
- Page 96 and 97: Am J Physiol Endocrinol Metab, 298,
- Page 98 and 99: Transgenic animal models and gene t
- Page 100 and 101: Ayuso E, Mingozzi F, Bosch F Curr G
- Page 102 and 103: Laboratory of Molecular Endocrinolo
- Page 104 and 105: Hospital de Cruces Diabetes Researc
- Page 106 and 107: Research grants International proje
- Page 108 and 109: Proinsulin and tyrosine hydroxilase
- Page 110 and 111: Genomic programming of beta cells I
- Page 112 and 113: Diabetes and obesity: biopathology
- Page 114 and 115: Utilidad de la ecografía arterial
- Page 116 and 117: Islet cell and stem cell physiology
- Page 118 and 119: in diabetic patients with chronic c
- Page 120 and 121: Liraglutide versus sitagliptin for
- Page 122 and 123: Unit of Cell Physiology and Nutriti
- Page 124 and 125: National projects Efectos a corto y
- Page 126 and 127: Altirriba J, Gasa R, Casas S, Ramí
- Page 128 and 129: Transcriptional mechanisms of pancr
- Page 131 and 132: Epilogue
- Page 133 and 134: Keyword index* Beta-cell signal tra
- Page 135 and 136: Association of selected ABC gene fa
- Page 137 and 138: Leiter LA, Levitt NS, Mareev V, Mar
- Page 139 and 140: Low body adiposity and high leptine
- Page 141 and 142: Alvaro A, Rosales R, Masana L, Vall
- Page 143: The apolipoprotein A5 (APOA5) gene