2010 AnnuAl REpoRT - Ciberdem

Metabolic and molecular disturbances in diabetes
Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona
www.diabetisiobesitat.org
Principal Investigator Anna Novials anovials@clinic.ub.es Associate researcher Joan Marc Servitja Postdoctoral fellows Maud Soty,
Paola Casini Research assistants Serafín Murillo, Laura Brugnara PhD students Montse Visa, Lisa Cadavez, Alba Moreno Lab technician
Carlos Castaño
Total IF: 10.946
Publications: 2, 1 in the first decile and 1 in the first quartile
With other CIBERDEM groups: 2
Research grants: 5
European projects: 1
National projects: 3
Autonomous Community projects: 1
Scientific collaborations within CIBERDEM: 3
Clinical trials: 1
Keywords
Islet amyloid polypeptide/amylin. Islet degeneration and
damage. Transcription factors. Exercise. Endothelium.
Main lines of research
-Mechanisms of pancreatic islet dysfunction in type 2
diabetes mellitus, in particular, the process of cytotoxicity
as induced by amyloidogenesis.
-Signalling and transcriptional networks in the pancreatic
beta cell, mainly related to the modulation of the
transcriptional programme under stress conditions.
-Impact of lifestyle on diabetes: metabolic and molecular
responses to exercise and nutrition in diabetic patients.
Publications*
Original articles
BACE2 plays a role in the insulin receptor trafficking in
pancreatic beta cells
Casas S, Casini P, Piquer S, Altirriba J, Soty M, Cadavez L,
Gomis R, Novials A
Am J Physiol Endocrinol Metab, 299, E1087-E1095 (2010)
IF: 4.395 first quartile. With other CIBERDEM groups: R Gomis
The role of transmembrane protein 27 (TMEM27) in islet
physiology and its potential use as a beta cell mass biomarker
*Only those published in 2010, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are
located in the first or second quartile of their subject category are included.
124 CibeRdem