Lipids and Arteriosclerosis Research Unit Institut d’Investigació Sanitària Pere Virgili, Hospital Universitari Sant Joan de Reus www.iispv.cat Principal Investigator Lluís Masana luis.masana@urv.cat Research directors Josep Ribalta, Rosa Solà Senior researchers Anna Cabré, Joan Carles Vallvé Associate researcher Núria Plana Nutritionist Jordi Merino Postdoctoral fellows Montserrat Guardiola, Rosa Maria Valls PhD students Gemma Aragonès, Úrsula Catalán, Raimon Ferré, Marta González, Iolanda Lázaro, Isabel Martorell, Anna Pedret, Paula Saavedra Lab manager Josefa Girona Lab technicians Mercedes Heras, Carme Buixadera, Sara Fernández, Roser Rosales Administrative staff Sílvia Solé Total IF: 49.910 Publications: 12, 6 of them in the first decile, 5 in the first quartile and 1 in the second quartile With other CIBERDEM groups: 4 With other CIBERs: 5 With other international groups: 1 Research grants: 4 National projects: 4 Scientific collaborations within CIBERDEM: 3 Clinical trials: 4 Spin-offs: 1 PhD theses: 4 Awards: 1 Keywords Genetics type 2 diabetes. Insulin sensitivity and resistance. Metabolic syndrome. Biomarkers and Imaging. Prevention of type 2 diabetes. Endothelium. Macrovascular disease. Nutrigenomics. Main lines of research -Atherogenic dyslipidaemia in diabetes, obesity and metabolic syndrome. -The characterization of plasma lipoprotein subclasses by NMR, metabolomics and lipidomics. -Adipose tissue dysfunction as a major determinant of AD. -Fatty Acid-Binding Proteins (FABPs) and insulin resistance in different tissues. -Fatty acids and adipokine-induced endothelial dysfunction. -AD and subclinical atherosclerosis. -FFA, extracellular matrix and artery wall dysfunction in diabetes. -The epigenetics of atherosclerosis. <strong>2010</strong> Annual Report 69
-The impact of nutrition on metabolic and cardiovascular risk. -Nutrigenomics. Publications* Original articles APOH is increased in the plasma and liver of type 2 diabetic patients with metabolic syndrome Castro A, Lázaro I, Selva DM, Céspedes E, Girona J, Plana N, Guardiola M, Cabré A, Simó R, Masana L Atherosclerosis, 209, 201-205 (<strong>2010</strong>) IF: 4.522 first decile. With other CIBERDEM groups: R Simó Effect of nut consumption on oxidative stress and the endothelial function in metabolic syndrome López-Uriarte P, Nogués R, Saez G, Bulló M, Romeu M, Masana L, Tormos C, Casas-Agustench P, Salas-Salvadó J Clin Nutr, 29, 373-380 (<strong>2010</strong>) IF: 3.247 first quartile. With other CIBERs: CIBEROBN Effect of the long-term regular intake of virgin olive oil on the phenolic metabolites in human fasting plasma Valls RM, Soler A, Girona J, Heras M, Romero MP, Covas MI, Solà R, Masana L, Motilva MJ J Pharm Biomed Anal, 53, 68-74 (<strong>2010</strong>) IF: 2.453 second quartile. With other CIBERs: CIBEROBN FABP4 plasma levels are increased in familial combined hiperlipidemias Cabré A, Lázaro I, Cofán M, Jarauta E, Plana N, Garcia-Otín AL, Ascaso JF, Ferré R, Civeira F, Ros E, Masana L J Lipid Res, 51, 1173-1178 (<strong>2010</strong>) IF: 4.917 first quartile. With other CIBERDEM groups: R Carmena. With other CIBERs: CIBEROBN Fatty acid-binding protein 4 is associated with endothelial dysfunction in patients with type 2 diabetes Aragonès G, Ferré R, Lázaro I, Cabré A, Plana N, Merino J, Heras M, Girona J, Masana L Atherosclerosis, 213, 329-331 (<strong>2010</strong>) IF: 4.522 first decile Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008 López-Miranda J, Pérez-Jiménez F, Ros E, De Caterina R, Badimón L, Covas MI, Escrich E, Ordovás JM, Soriguer F, Abiá R, de la Lastra CA, Battino M, Corella D, Chamorro- Quirós J, Delgado-Lista J, Giugliano D, Esposito K, Estruch R, Fernandez-Real JM, Gaforio JJ, La Vecchia C, Lairon D, López-Segura F, Mata P, Menéndez JA, Muriana FJ, Osada J, Panagiotakos DB, Paniagua JA, Pérez-Martinez P, Perona J, Peinado MA, Pineda-Priego M, Poulsen HE, Quiles JL, Ramírez-Tortosa MC, Ruano J, Serra-Majem L, Solá R, Solanas M, Solfrizzi V, de la Torre-Fornell R, Trichopoulou A, Uceda M, Villalba-Montoro JM, Villar-Ortiz JR, Visioli F, Yiannakouris N Nutr Metab Cardiovasc Dis, 20, 284-294 (<strong>2010</strong>) IF: 3.517 first quartile. With other international groups. With other CIBERDEM groups: F Soriguer. With other CIBERs: CIBEROBN Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids Alvaro A, Rosales R, Masana L, Vallvé JC J Nutr Biochem, 21, 518-525 (<strong>2010</strong>) IF: 4.288 first quartile Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial Solà R, Bruckert E, Valls RM, Narejos S, Luque X, Castro- Cabezas M, Doménech G, Torres F, Heras M, Farrés X, Vaquer JV, Martínez JM, Almaraz MC, Anguera A Atherosclerosis, 211, 630-637 (<strong>2010</strong>) IF: 4.522 first decile. With other CIBERDEM groups: F Soriguer The APOA5-1131 T>C variant enhances the association between RBP4 and hypertriglyceridemia in diabetes Cabré A, Lázaro I, Girona J, Manzanares JM, Marimón F, Plana N, Guardiola M, Heras M, Masana L Nutr Metab Cardiovasc Dis, 20, 243-248 (<strong>2010</strong>) IF: 3.517 first quartile Monitoring cells in the cell-culture cabinet. The apolipoprotein A5 gene predisposes Caucasian children to elevated triglycerides and vitamin E (Four Provinces Study) Guardiola M, Ribalta J, Gómez-Coronado D, Lasunción MA, de Oya M, Garcés C Atherosclerosis, 212, 543-547 (<strong>2010</strong>) IF: 4.511 first decile. With other CIBERs: CIBEROBN *Only those published in <strong>2010</strong>, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are located in the first or second quartile of their subject category are included. 70 CibeRdem
- Page 1 and 2:
2010 Annual Report CIBERDEM Centro
- Page 4 and 5:
Letter from the Scientific Director
- Page 6 and 7:
Contents Prologue Research results
- Page 8 and 9:
Research results Publications In 20
- Page 10 and 11:
Project management Introduction The
- Page 12 and 13:
Training programme Introduction The
- Page 14 and 15:
Outreach activities CIBERDEM Fundra
- Page 16 and 17:
More about CIBERDEM The Centro de I
- Page 18 and 19:
Human Resources In 2010, CIBERDEM h
- Page 20 and 21: Transversal projects Di@bet.es Stud
- Page 22 and 23: Di@bet.es Study Introduction Attemp
- Page 24 and 25: CIBERDEM Projects Introduction CIBE
- Page 26 and 27: girls (girls born small for gestati
- Page 28 and 29: Biobank Introduction and objectives
- Page 30 and 31: Metabolomics Platform Introduction
- Page 33 and 34: Area 1 Insulin signalling and resis
- Page 35 and 36: Diabetes and cardiovascular Faculta
- Page 37 and 38: Metabolomics Platform Universitat R
- Page 39 and 40: Obesity, inflammation and insulin r
- Page 41 and 42: Mechanisms of control of glucose an
- Page 43 and 44: Metabolic engineering and diabetes
- Page 45 and 46: Molecular mechanisms of insulin res
- Page 47 and 48: Molecular characteristics, and acti
- Page 49 and 50: Heterogenic and polygenic diseases.
- Page 51: Principal Investigator: Antonio Zor
- Page 54 and 55: The research activity of this area
- Page 56 and 57: The cationic cluster of group IVA p
- Page 58 and 59: agent that affects the enterohepati
- Page 60 and 61: Dyslipidaemia, inflammation and end
- Page 62 and 63: Daño orgánico en la diabetes mell
- Page 64 and 65: Proteomic analysis of plasma in the
- Page 66 and 67: Prenatal growth restriction and sub
- Page 68 and 69: The effects of metformin on cardiov
- Page 72 and 73: Review Pitavastatin - from clinical
- Page 74 and 75: Diabetobe Hospital Clínico San Car
- Page 76 and 77: Scientific collaborations within CI
- Page 78 and 79: Atherosclerosis, 209, 201-205 (2010
- Page 80 and 81: Solvay, SA: 2008-2010 Principal Inv
- Page 82 and 83: Endocrinology and Nutrition Service
- Page 84 and 85: Prevención de la Diabetes mellitus
- Page 86 and 87: Pharmacological targets in inflamma
- Page 88 and 89: Diabetes and Metabolic Associated D
- Page 90 and 91: Autonomous Community project Grup d
- Page 92 and 93: Area 3 of CIBERDEM comprises thirte
- Page 94 and 95: Escrivá F, Alvarez C J Mol Endocri
- Page 96 and 97: Am J Physiol Endocrinol Metab, 298,
- Page 98 and 99: Transgenic animal models and gene t
- Page 100 and 101: Ayuso E, Mingozzi F, Bosch F Curr G
- Page 102 and 103: Laboratory of Molecular Endocrinolo
- Page 104 and 105: Hospital de Cruces Diabetes Researc
- Page 106 and 107: Research grants International proje
- Page 108 and 109: Proinsulin and tyrosine hydroxilase
- Page 110 and 111: Genomic programming of beta cells I
- Page 112 and 113: Diabetes and obesity: biopathology
- Page 114 and 115: Utilidad de la ecografía arterial
- Page 116 and 117: Islet cell and stem cell physiology
- Page 118 and 119: in diabetic patients with chronic c
- Page 120 and 121:
Liraglutide versus sitagliptin for
- Page 122 and 123:
Unit of Cell Physiology and Nutriti
- Page 124 and 125:
National projects Efectos a corto y
- Page 126 and 127:
Altirriba J, Gasa R, Casas S, Ramí
- Page 128 and 129:
Transcriptional mechanisms of pancr
- Page 131 and 132:
Epilogue
- Page 133 and 134:
Keyword index* Beta-cell signal tra
- Page 135 and 136:
Association of selected ABC gene fa
- Page 137 and 138:
Leiter LA, Levitt NS, Mareev V, Mar
- Page 139 and 140:
Low body adiposity and high leptine
- Page 141 and 142:
Alvaro A, Rosales R, Masana L, Vall
- Page 143 and 144:
The apolipoprotein A5 (APOA5) gene
- Page 145 and 146:
www.ciberdem.org/annualreport CIBER