2010 AnnuAl REpoRT - Ciberdem

Metabolic engineering and diabetes therapy
Institut de Recerca Biomèdica, Barcelona
www.irbbarcelona.org
Principal Investigator Joan J Guinovart guinovart@irbbarcelona.org Associate researchers Joaquim Calbó, María del Mar García Postdoctoral
fellows Adelaida Díaz, Jordi Duran, Carlos Rodríguez, Delia Zafra Research assistant Anna Adrover PhD students Óscar Blanco, Carles
Martínez, Laura Nocito, Isabel Sáez, Jordi Vallès Lab technicians Emma Veza, Ester Guerra Administrative staff Carolina Sánchez
Total IF: 5.328
Publications: 1, in the first quartile
Research grants: 4
National projects: 1
Autonomous Community projects: 1
Private funds: 2
Scientific collaborations within CIBERDEM: 2
Awards: 2
Keywords
Carbohydrate metabolism. Insulin sensitivity and
resistance. Metabolic syndrome. Oral pharmacological
agents. Retinopathy.
Main lines of research
-Mechanisms of control of glucose storage in the liver and
muscle and their alterations in diabetes mellitus.
-The consequences of altered glycogen deposition
in various tissues in diabetes mellitus and in several
neurodegenerative diseases.
-The identification of potential molecular targets that
regulate glycogen metabolism and the characterization of
novel compounds with anti-diabetic action.
Publications*
Original article
Hepatic overexpression of a constitutively active form of
liver glycogen synthase improves glucose homeostasis
Ros S, Zafra D, Valles-Ortega J, García-Rocha M, Forrow S,
Domínguez J, Calbó J, Guinovart JJ
J Biol Chem, 285, 37170-37177 (2010)
IF: 5.328 first quartile
Research grants
National project
Estudio de un nuevo mecanismo de regulación del
metabolismo del glucógeno. Análisis de las implicaciones
patológicas de la acumulación anómala de polímeros de
glucosa
Ministerio de Ciencia e Innovación, BFU2008-00769:
2009-2011
Principal Investigator: Joan J Guinovart
Autonomous Community project
Ayudas de apoyo a grupos de investigación
Generalitat de Catalunya (AGAUR), SGR2009-1176:
2009-2013
Principal Investigator: Joan J Guinovart
*Only those published in 2010, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are
located in the first or second quartile of their subject category are included.
42 CibeRdem