2010 AnnuAl REpoRT - Ciberdem

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Proinsulin and tyrosine hydroxilase in development and differentiation Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid www.cib.csic.es Principal Investigator Flora de Pablo fdepablo@cib.csic.es Associate researcher Catalina Hernández Postdoctoral fellow Patricia Vázquez Lab technician Cayetana Murillo Total IF: 4.395 Publications: 1, in the first quartile With other CIBERDEM groups: 1 Research grants: 1 National projects: 1 Patents: 1 Keywords Catecholamines. Hormone receptors. Proinsulin. Islet development. Insulin sensitivity and resistance. Main lines of research To characterize TH expression pattern in mouse pancreas development and the analysis of TH function by studying pancreatic cell markers in TH-/- developing mice. Publications* Original article Signaling and biological effects of glucagon-like peptide 1 on the differentiation of mesenchymal stem cells from human bone marrow Sanz C, Vázquez P, Blázquez C, Barrio PA, Alvarez M del M, Blázquez E Am J Physiol Endocrinol Metab, 298, E634-643 (2010) IF: 4.395 first quartile. With other CIBERDEM groups: E Blázquez Research grants National project Transcritos quimera y otras formas atípicas de regulación génica y sus implicaciones en el desarrollo temprano Ministerio de Ciencia e Innovación, BFU2007-61055: 2007-2010 Principal Investigator: Flora de Pablo Patents National patent Uso de la proinsulina para la elaboración de una composición farmacéutica neuroprotectora, composición *Only those published in 2010, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are located in the first or second quartile of their subject category are included. 2010 Annual Report 107
terapéutica que la contiene y sus aplicaciones Patent application number: ES2331342B1 Inventors: EJ de la Rosa Cano, F de Pablo Dávila, P Boya Tremoleda, S Corrochano Sánchez, P de la Villa Polo, R Barhoum Tannous and F Bosch Tubert CIB-CSIC, Universitat Autònoma de Barcelona and Universidad de Alcalá de Henares (2010) ■ Effects of dopamine treatment on embryonic pancreas in organotypic culture. 108 CibeRdem
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2010 Annual Report CIBERDEM Centro
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Letter from the Scientific Director
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Contents Prologue Research results
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Research results Publications In 20
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Project management Introduction The
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Training programme Introduction The
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Outreach activities CIBERDEM Fundra
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More about CIBERDEM The Centro de I
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Human Resources In 2010, CIBERDEM h
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Transversal projects Di@bet.es Stud
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Di@bet.es Study Introduction Attemp
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CIBERDEM Projects Introduction CIBE
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girls (girls born small for gestati
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Biobank Introduction and objectives
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Metabolomics Platform Introduction
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Area 1 Insulin signalling and resis
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Diabetes and cardiovascular Faculta
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Metabolomics Platform Universitat R
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Obesity, inflammation and insulin r
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Mechanisms of control of glucose an
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Metabolic engineering and diabetes
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Molecular mechanisms of insulin res
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Molecular characteristics, and acti
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Heterogenic and polygenic diseases.
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Principal Investigator: Antonio Zor
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The research activity of this area
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The cationic cluster of group IVA p
Page 58 and 59: agent that affects the enterohepati
Page 60 and 61: Dyslipidaemia, inflammation and end
Page 62 and 63: Daño orgánico en la diabetes mell
Page 64 and 65: Proteomic analysis of plasma in the
Page 66 and 67: Prenatal growth restriction and sub
Page 68 and 69: The effects of metformin on cardiov
Page 70 and 71: Lipids and Arteriosclerosis Researc
Page 72 and 73: Review Pitavastatin - from clinical
Page 74 and 75: Diabetobe Hospital Clínico San Car
Page 76 and 77: Scientific collaborations within CI
Page 78 and 79: Atherosclerosis, 209, 201-205 (2010
Page 80 and 81: Solvay, SA: 2008-2010 Principal Inv
Page 82 and 83: Endocrinology and Nutrition Service
Page 84 and 85: Prevención de la Diabetes mellitus
Page 86 and 87: Pharmacological targets in inflamma
Page 88 and 89: Diabetes and Metabolic Associated D
Page 90 and 91: Autonomous Community project Grup d
Page 92 and 93: Area 3 of CIBERDEM comprises thirte
Page 94 and 95: Escrivá F, Alvarez C J Mol Endocri
Page 96 and 97: Am J Physiol Endocrinol Metab, 298,
Page 98 and 99: Transgenic animal models and gene t
Page 100 and 101: Ayuso E, Mingozzi F, Bosch F Curr G
Page 102 and 103: Laboratory of Molecular Endocrinolo
Page 104 and 105: Hospital de Cruces Diabetes Researc
Page 106 and 107: Research grants International proje
Page 110 and 111: Genomic programming of beta cells I
Page 112 and 113: Diabetes and obesity: biopathology
Page 114 and 115: Utilidad de la ecografía arterial
Page 116 and 117: Islet cell and stem cell physiology
Page 118 and 119: in diabetic patients with chronic c
Page 120 and 121: Liraglutide versus sitagliptin for
Page 122 and 123: Unit of Cell Physiology and Nutriti
Page 124 and 125: National projects Efectos a corto y
Page 126 and 127: Altirriba J, Gasa R, Casas S, Ramí
Page 128 and 129: Transcriptional mechanisms of pancr
Page 131 and 132: Epilogue
Page 133 and 134: Keyword index* Beta-cell signal tra
Page 135 and 136: Association of selected ABC gene fa
Page 137 and 138: Leiter LA, Levitt NS, Mareev V, Mar
Page 139 and 140: Low body adiposity and high leptine
Page 141 and 142: Alvaro A, Rosales R, Masana L, Vall
Page 143 and 144: The apolipoprotein A5 (APOA5) gene
Page 145 and 146: www.ciberdem.org/annualreport CIBER
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2010 AnnuAl REpoRT - Ciberdem

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