2010 AnnuAl REpoRT - Ciberdem

Genomic programming of beta cells
Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona
www.betacellregulation.net
Principal Investigator Jorge Ferrer jferrer@clinic.ub.es Postdoctoral fellows Ildem Akerman, Miguel Ángel Maestro, Lorenzo Pasquali,
Santiago Rodríguez PhD students Ignasi Moran, Myriam Solar, Joris van Arensbergen, Nikolina Nakic, Miguel A Correa Lab manager
Carme Sanahuja Lab technician Xavier Garcia, Vanesa Grau
Total IF: 64.590
Publications: 4, 3 of them in the first decile and 1 in the first quartile
With other CIBERDEM groups: 2
With other CIBERs: 1
With other international groups: 3
Research grants: 5
European projects: 2
National projects: 2
Private funds: 1
Scientific collaborations within CIBERDEM: 1
Keywords
Genetics type 2 diabetes. Genomics. Islet development.
Transcription factors.
Main lines of research
-Mouse genetic analysis of beta-cell regulation.
-Understanding the epigenome of pancreatic beta cells
and its implications for the development, plasticity and
growth of beta cells.
-The regeneration of pancreatic beta cells.
Publications*
Original articles
A map of open chromatin in human pancreatic islets
Gaulton KJ, Nammo T, Pasquali L, Simon JM, Giresi PG,
Fogarty MP, Panhuis TM, Mieczkowski P, Secchi A, Bosco D,
Berney T, Montanya E, Mohlke KL, Lieb JD, Ferrer J
Nat Genet, 42, 255-259 (2010)
IF: 34.284 first decile. With other international groups. With
other CIBERDEM groups: E Montanya
Derepression of Polycomb targets during pancreatic
organogenesis allows insulin-producing beta-cells to adopt
a neural gene activity program
van Arensbergen J, García-Hurtado J, Moran I, Maestro
*Only those published in 2010, with CIBERDEM listed among the affiliations, which are related to CIBERDEM’s field of research and are
located in the first or second quartile of their subject category are included.
2010 Annual Report
109